An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
about
Bile acids as endogenous etiologic agents in gastrointestinal cancerIdentification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearanceThe vitamin D-antimicrobial peptide pathway and its role in protection against infectionReduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alphaBile acids: regulation of synthesisInduction of bilirubin clearance by the constitutive androstane receptor (CAR)Bile acids: emerging role in management of liver diseasesBiology of PXR: role in drug-hormone interactionsBile acid metabolism and signalingModulation of xenobiotic receptors by steroidsBile acids, obesity, and the metabolic syndromePeroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzymeIdentification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesBile acid signaling in metabolic disease and drug therapyThe farnesoid X-receptor is an essential regulator of cholesterol homeostasisFXR-mediated regulation of eNOS expression in vascular endothelial cellsDisturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse modelPregnane X receptor and natural products: beyond drug-drug interactionsEvolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile saltsNovel functions of PXR in cardiometabolic disease.Retinoic acid actions through mammalian nuclear receptors.Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)Evolution of pharmacologic specificity in the pregnane X receptor.Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesisIntestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid.The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptorClinical application of transcriptional activators of bile salt transporters.Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challengePregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Cholesterol detoxification by the nuclear pregnane X receptor.2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.Prosteatotic genes are associated with unsaturated fat suppression of saturated fat-induced hepatic steatosis in C57BL/6 mice.A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway.Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinomaActivation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).
P2860
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P2860
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
An essential role for nuclear ...... ion of cholestatic bile acids.
@ast
An essential role for nuclear ...... ion of cholestatic bile acids.
@en
An essential role for nuclear ...... ion of cholestatic bile acids.
@nl
type
label
An essential role for nuclear ...... ion of cholestatic bile acids.
@ast
An essential role for nuclear ...... ion of cholestatic bile acids.
@en
An essential role for nuclear ...... ion of cholestatic bile acids.
@nl
prefLabel
An essential role for nuclear ...... ion of cholestatic bile acids.
@ast
An essential role for nuclear ...... ion of cholestatic bile acids.
@en
An essential role for nuclear ...... ion of cholestatic bile acids.
@nl
P2093
P2860
P356
P1476
An essential role for nuclear ...... tion of cholestatic bile acids
@en
P2093
P2860
P304
P356
10.1073/PNAS.051014398
P407
P577
2001-03-01T00:00:00Z