Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
about
VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelityPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Recombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemA WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactionsElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingAnalysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locusElucidation of IgH intronic enhancer functions via germ-line deletionMobilization of RAG-generated signal ends by transposition and insertion in vivoLocalized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.The RAG2 C terminus suppresses genomic instability and lymphomagenesis.Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.Artemis sheds new light on V(D)J recombination.Regulation of immunoglobulin heavy-chain gene rearrangements.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.RAG Represents a Widespread Threat to the Lymphocyte Genome.Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination.A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinaseBone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.Evidence for Ku70/Ku80 association with full-length RAG1.Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctionsLeaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2.Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences.V(D)J Recombination: Mechanism, Errors, and Fidelity.New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.CTCF-binding elements mediate control of V(D)J recombinationRAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks
P2860
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P2860
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
@ast
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
@en
type
label
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
@ast
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
@en
prefLabel
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
@ast
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
@en
P2093
P2860
P356
P1476
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice
@en
P2093
Chengming Zhu
Craig H Bassing
Darryll D Dudley
Frederick W Alt
Jeffrey DeVido
Robert J Monroe
Scott Whitlow
P2860
P304
P356
10.1084/JEM.20030627
P407
P577
2003-10-27T00:00:00Z