Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
about
Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipidsBrown and Beige Fat: Molecular Parts of a Thermogenic MachineEvidence of cancer-promoting roles for AMPK and related kinasesThe signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.Regulation of glucose homeostasis by KSR1 and MARK2.Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.Involvement of SIK3 in glucose and lipid homeostasis in mice.Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis.Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes.Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis.Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesityEpigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate LevelsMark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes.Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells.Protein Scaffolds Control Localized Protein Kinase Cζ Activity.LKB1; linking cell structure and tumor suppression.The molecular mechanisms that underlie the tumor suppressor function of LKB1.LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.ssc-miR-7134-3p regulates fat accumulation in castrated male pigs by targeting MARK4 gene.Role of LKB1-SAD/MARK pathway in neuronal polarization.Cellular polarity in aging: role of redox regulation and nutrition.The CLASP2 Protein Interaction Network in Adipocytes Links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and Identifies SOGA1 as a Microtubule-Associated Protein.Evaluation of the Genisys4, a bench-top preclinical PET scannerPartitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development.LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cellsLKB1 regulates pancreatic beta cell size, polarity, and function.SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways.Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.Metabolic control of regulatory T cell (Treg) survival and function by Lkb1.MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia.[Advances of LKB1-AMPK-mTOR Signaling Pathway in Tumor].
P2860
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P2860
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Loss of the Par-1b/MARK2 polar ...... sulin hypersensitivity in vivo
@ast
Loss of the Par-1b/MARK2 polar ...... sulin hypersensitivity in vivo
@en
type
label
Loss of the Par-1b/MARK2 polar ...... sulin hypersensitivity in vivo
@ast
Loss of the Par-1b/MARK2 polar ...... sulin hypersensitivity in vivo
@en
prefLabel
Loss of the Par-1b/MARK2 polar ...... sulin hypersensitivity in vivo
@ast
Loss of the Par-1b/MARK2 polar ...... sulin hypersensitivity in vivo
@en
P2093
P2860
P356
P1476
Loss of the Par-1b/MARK2 polar ...... sulin hypersensitivity in vivo
@en
P2093
Cheol Soo Choi
David Piwnica-Worms
Helen Piwnica-Worms
Hyo-Jeong Kim
Jason K Kim
Jochen Lennerz
Jonathan B Hurov
Julie L Prior
Lynn S White
P2860
P304
P356
10.1073/PNAS.0701179104
P407
P577
2007-03-19T00:00:00Z