LKB1 regulates pancreatic beta cell size, polarity, and function. - Wikidata - wikimedia - TriplyDB

LKB1 regulates pancreatic beta cell size, polarity, and function.

LKB1 regulates pancreatic beta cell size, polarity, and function.

http://www.wikidata.org/entity/Q41870049

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Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells The required beta cell research for improving treatment of type 2 diabetes Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3 Bistability: requirements on cell-volume, protein diffusion, and thermodynamics New Roles of Lkb1 in Regulating Adipose Tissue Development and Thermogenesis.Subcellular glucose exposure biases the spatial distribution of insulin granules in single pancreatic beta cells.Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature.Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.Cell polarity defines three distinct domains in pancreatic β-cells.Dissecting the role of AMP-activated protein kinase in human diseases.LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.Regulation of glucose homeostasis by KSR1 and MARK2.Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.LKB1 and AMPK differentially regulate pancreatic β-cell identity.mTOR links incretin signaling to HIF induction in pancreatic beta cells.Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes.Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity Differential effects on β-cell mass by disruption of Bardet-Biedl syndrome or Alstrom syndrome genes.Adaptive changes of human islets to an obesogenic environment in the mouse.Fetal PGC-1α overexpression programs adult pancreatic β-cell dysfunction SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells.SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling.Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4 Conditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function.Dysregulation of mTOR activity through LKB1 inactivation.Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.The LKB1/AMPK polarity pathway.Molecular mechanisms of tumor suppression by LKB1.

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P2860

LKB1 regulates pancreatic beta cell size, polarity, and function.

http://www.wikidata.org/entity/Q41870049

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

LKB1 regulates pancreatic beta cell size, polarity, and function.

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type

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LKB1 regulates pancreatic beta cell size, polarity, and function.

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LKB1 regulates pancreatic beta cell size, polarity, and function.

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J.CMET.2009.08.010

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Cell Metabolism

P1476

LKB1 regulates pancreatic beta cell size, polarity, and function.

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P2093

Avital Swisa

http://www.w3.org/2001/XMLSchema#string

Christian J Stoeckert

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Elisabetta Manduchi

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Helen Piwnica-Worms

http://www.w3.org/2001/XMLSchema#string

Jochen K Lennerz

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Judith Magenheim

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M Alan Permutt

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Miri Stolovich-Rain

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Nabeel Bardeesy

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Oded Meyuhas

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

TSC2 mediates cellular energy response to control cell growth and survival

The LKB1 tumor suppressor negatively regulates mTOR signaling

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

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4

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10

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Nabeel Bardeesy

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2009-10-01T00:00:00Z

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26875050

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2790403

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