Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis.
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Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytesGlobal transcriptional characterization of SP and MP cells from the myogenic C2C12 cell line: effect of FGF6.Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling.Up-regulation of AT(1) and AT(2) receptors in postinfarcted hypertrophied myocytes and stretch-mediated apoptotic cell death.Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosisAngiotensinII preconditioning promotes angiogenesis in vitro via ERKs phosphorylationApoptosis and oncosis in acute coronary syndromes: assessment and implications.A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loopMdm2 in growth signaling and cancer.Regulation of MDMX expression by mitogenic signaling.IGF-1 expression in infarcted myocardium and MGF E peptide actions in rat cardiomyocytes in vitro.Growth hormone is permissive for neoplastic colon growth.Additive interaction between the renin-angiotensin system and lipid metabolism for cancer in type 2 diabetes.Innate regeneration in the aging heart: healing from within.The role of insulin-like growth factor during a postischemic period - new insights into pathophysiologic pathways in cardiac tissue.IGF-1 and atherothrombosis: relevance to pathophysiology and therapy.Proinflammatory CXCL12-CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice.ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability.Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.Hypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer--evaluation of the prognostic significance of these agents.Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization.Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase.Regulation of p53 and MDM2 activity by MTBP.Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro.Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage.Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation.Load-dependent induction of apoptosis in multicellular myocardial preparations.Cyclical mechanical stretch-induced apoptosis in myocytes from young rats but necrosis in myocytes from old rats.IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose.Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice.Upregulation of cardiac insulin-like growth factor-I receptor by ACE inhibition after myocardial infarction: potential role in remodeling.
P2860
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P2860
Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Insulin-like growth factor-1 i ...... nd stretch-mediated apoptosis.
@ast
Insulin-like growth factor-1 i ...... nd stretch-mediated apoptosis.
@en
type
label
Insulin-like growth factor-1 i ...... nd stretch-mediated apoptosis.
@ast
Insulin-like growth factor-1 i ...... nd stretch-mediated apoptosis.
@en
prefLabel
Insulin-like growth factor-1 i ...... nd stretch-mediated apoptosis.
@ast
Insulin-like growth factor-1 i ...... nd stretch-mediated apoptosis.
@en
P2093
P2860
P1476
Insulin-like growth factor-1 i ...... nd stretch-mediated apoptosis.
@en
P2093
A Malhotra
J Kajstura
P P Claudio
P2860
P304
P356
10.1016/S0002-9440(10)65302-3
P407
P577
1999-02-01T00:00:00Z