about
Cullin family proteins and tumorigenesis: genetic association and molecular mechanismsFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisGenetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesUbiquitination-induced fluorescence complementation (UiFC) for detection of K48 ubiquitin chains in vitro and in live cellsUbiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancerOvercoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesisEndothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.Maintaining glycogen synthase kinase-3 activity is critical for mTOR kinase inhibitors to inhibit cancer cell growth.Targeting the neddylation pathway to suppress the growth of prostate cancer cells: therapeutic implication for the men's cancer.MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinomaInactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid.The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic targetErioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1miR-194 targets RBX1 gene to modulate proliferation and migration of gastric cancer cells.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapyGenetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease.Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesisSCF ubiquitin ligases in the maintenance of genome stability.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic applicationSuppression of glioblastoma by targeting the overactivated protein neddylation pathway.Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma.Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells.Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapyProteasome inhibition rescues clinically significant unstable variants of the mismatch repair protein Msh2.Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells.Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivoRole of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer.Radiosensitization by the investigational NEDD8-activating enzyme inhibitor MLN4924 (pevonedistat) in hormone-resistant prostate cancer cells.The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis.The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.Suppression of tumor angiogenesis by targeting the protein neddylation pathway.E2/Estrogen receptor/sjogren syndrome-associated autoantigen relieves coactivator activator-induced G1/S arrest to promote breast tumorigenicity.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases.Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.Cullin-RING Ligases as attractive anti-cancer targets.
P2860
Q26822657-6133FA2E-9B3D-4FC9-B159-F314BA71B509Q26998944-EA7403BE-C7F1-43A4-97ED-7F124C9C7C31Q27027897-3EEA0F5E-6DFB-47EA-99D2-9552E38B006AQ27307830-E33323F5-3A4D-4D63-B17A-804685204845Q28674964-FF15F3D6-312E-4E77-8448-DB7AF1237EC1Q30410498-13E6D3A8-67F6-4DC2-9697-9237BC1706DBQ30569769-9B5885A0-CF94-4511-9726-51CDC06B2ECDQ33594656-0E4766BC-E0E8-420F-8AB6-C44954D16156Q33645556-3EBCE697-469F-4F1C-98BB-4D7DC9145B0DQ33908666-D10EC7B3-B038-4CFE-8108-03503783A4EAQ33912016-7447AAA1-1A50-4AD0-9BEB-F44598D75EF3Q34081767-A9C91DD8-C14C-44F5-BB47-A208BFE6A1B9Q34212168-C9155215-CD67-4100-934D-E8EBA23C0084Q34365897-C5A92349-BFCB-4221-BA3E-724C649481B5Q34441649-4C4FB95B-9759-42ED-87EF-E06E5E4B46ACQ34448810-94BA29C3-0A69-41E8-A869-1BA627685BFDQ34563129-8BA5C59F-C585-480B-B82D-019D41E75A3DQ34996445-432028FB-F4CF-4724-B4A1-5AD2D3EF873FQ35653286-CBD869AA-4BE0-458D-843A-4C848AF67E80Q35697259-B640D628-E282-4EAE-82CC-47EF47B925E8Q35754115-B2155C28-252E-47CC-9119-BE9F02ACAECDQ36062128-11326C8F-D209-419D-A088-F09C2A374543Q36082492-1D8E533C-A8FB-4239-9FDE-DD0897E734A3Q36146344-217FA257-4223-4B5F-82AA-023913AD332CQ36215406-D5DDDA33-2FCC-413B-9692-B8C7F080166AQ36334266-A29B8D80-7DED-45AE-AA54-7B7A1BAD6B9BQ36512211-1BA4E481-4E6C-48FD-8F24-B8D635B832EFQ36560489-8E4F74BD-2E05-4047-94EA-2E2DEDE858BEQ36785312-C9F0EEC8-4217-4941-8B81-28A182505A28Q36957246-4DB8489D-6D2D-4C86-8237-A5C27A9C09BDQ37388126-9D4A93D6-0FBC-4BA8-B063-041F3571982DQ37437499-404DB62F-C306-4097-B322-0CC3A238C4E6Q37583704-86277BC4-82A7-4297-8C68-8019E48A462BQ37591349-2DD2C002-23F4-4960-862B-8CF84048C87DQ37620640-EA4E625F-39E7-4524-BABF-AAB986F646EBQ37713636-A85CC3C9-C720-461D-A6DE-135D4BEB7764Q37989861-0659012D-A7B1-4B72-A048-D8D9A22682C1Q38052131-964E8BFA-9FB6-41FA-8750-4BF6EE7E5D75Q38058483-2F1BCFBB-1D30-4184-9ABF-3C8C1B45AABAQ38059746-3C9E455E-057F-4115-9958-FB7798FB7490
P2860
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
SCF E3 ubiquitin ligases as anticancer targets.
@ast
SCF E3 ubiquitin ligases as anticancer targets.
@en
type
label
SCF E3 ubiquitin ligases as anticancer targets.
@ast
SCF E3 ubiquitin ligases as anticancer targets.
@en
prefLabel
SCF E3 ubiquitin ligases as anticancer targets.
@ast
SCF E3 ubiquitin ligases as anticancer targets.
@en
P2860
P1476
SCF E3 ubiquitin ligases as anticancer targets.
@en
P2860
P304
P356
10.2174/156800911794519734
P577
2011-03-01T00:00:00Z