Hypersensitive site 4 of the human beta globin locus control region.
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Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partnerIn vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reactionhMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionThe locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Dividing the empire: boundary chromatin elements delimit the territory of enhancers.Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic miceSynthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.The two zinc finger-like domains of GATA-1 have different DNA binding specificitiesGeneration of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.The beta-globin locus control region versus gene therapy vectors: a struggle for expression.An Erythroid-Specific Chromatin Opening Element Increases β-Globin Gene Expression from Integrated Retroviral Gene Transfer Vectors.Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell-based gene therapy.LCR/MEL: a versatile system for high-level expression of heterologous proteins in erythroid cells.Characterization of the factors binding to a PEPCK gene upstream hypersensitive site with LCR activity.Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression.A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenesThe beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.Synergism between hypersensitive sites confers long-range gene activation by the beta-globin locus control region.Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.The human growth hormone gene is regulated by a multicomponent locus control region.Essential role of NF-E2 in remodeling of chromatin structure and transcriptional activation of the epsilon-globin gene in vivo by 5' hypersensitive site 2 of the beta-globin locus control regionA single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.Mechanism of DNase I hypersensitive site formation within the human globin locus control region.Transcriptional mechanisms underlying hemoglobin synthesis.Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vectorActivation of the beta-globin locus control region precedes commitment to the erythroid lineage.Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structureGlobin gene switching. In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.Slow and Steady Wins The Race? Progress in the Development of Vectors for Gene Therapy of β-Thalassemia and Sickle Cell Disease.Microsatellite and single nucleotide polymorphisms in the β-globin locus control region-hypersensitive Site 2: SPECIFICITY of Tunisian βs chromosomes.Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability.Sequences within and flanking hypersensitive sites 3 and 2 of the beta-globin locus control region required for synergistic versus additive interaction with the epsilon-globin gene promoter.Multiple regions of p45 NF-E2 are required for beta-globin gene expression in erythroid cells.
P2860
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P2860
Hypersensitive site 4 of the human beta globin locus control region.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Hypersensitive site 4 of the human beta globin locus control region.
@ast
Hypersensitive site 4 of the human beta globin locus control region.
@en
type
label
Hypersensitive site 4 of the human beta globin locus control region.
@ast
Hypersensitive site 4 of the human beta globin locus control region.
@en
prefLabel
Hypersensitive site 4 of the human beta globin locus control region.
@ast
Hypersensitive site 4 of the human beta globin locus control region.
@en
P2093
P2860
P356
P1476
Hypersensitive site 4 of the human beta globin locus control region.
@en
P2093
Grosveld F
Hanscombe O
Philipsen S
P2860
P304
P356
10.1093/NAR/19.7.1413
P407
P577
1991-04-01T00:00:00Z