Aurora kinases: shining lights on the therapeutic horizon? - Wikidata - wikimedia - TriplyDB

Aurora kinases: shining lights on the therapeutic horizon?

Aurora kinases: shining lights on the therapeutic horizon?

http://www.wikidata.org/entity/Q36210257

about

Identification of Ski as a target for Aurora A kinase Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2 HEF1-dependent Aurora A activation induces disassembly of the primary cilium Structure of Aurora B–INCENP in complex with barasertib reveals a potential transinhibitory mechanism HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks A RasGAP SH3 peptide aptamer inhibits RasGAP-Aurora interaction and induces caspase-independent tumor cell death Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity Evolution of resistance to Aurora kinase B inhibitors in leukaemia cells A phase I dose-escalation study of danusertib (PHA-739358) administered as a 24-hour infusion with and without granulocyte colony-stimulating factor in a 14-day cycle in patients with advanced solid tumors.In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases.Esophageal adenocarcinoma: treatment modalities in the era of targeted therapy.Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A.Recognizing and exploiting differences between RNAi and small-molecule inhibitors.Rapid calcium-dependent activation of Aurora-A kinase.A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia.Breast cancer biomarker discovery in the functional genomic age: a systematic review of 42 gene expression signatures.Identification of an Aurora kinase inhibitor specific for the Aurora B isoform.The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target Meta-analysis of gene expression in relapsed childhood B-acute lymphoblastic leukemia Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)Development of new cancer therapeutic agents targeting mitosis.Emerging therapies for colorectal cancer.Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase The potential role of Aurora kinase inhibitors in haematological malignancies.Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.Aurora kinase inhibitors: progress towards the clinic Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny.Preclinical testing of selective Aurora kinase inhibitors on a medullary thyroid carcinoma-derived cell line.Structural studies of B-type Aurora kinase inhibitors using computational methods.Aurora B inhibitor barasertib and cytarabine exert a greater-than-additive cytotoxicity in acute myeloid leukemia cells.SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors.Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors.Role of CD200 expression in regulation of metastasis of EMT6 tumor cells in mice.

P2860

Q24304083-281BBB4C-CB3F-4E60-9916-5526893E4D88 Q24318313-8DEDFA7A-DCD2-4217-B7E0-2C83324E3B37 Q24647111-A4017947-D5EE-42C0-B9AF-EC9C1EDCD378 Q27682016-4CDDEDF7-E747-428B-B27F-A999DC8F920D Q28297459-24C0DA25-53A9-48A0-9CDF-DB85264199FD Q28473249-942E97C5-A261-4A0C-94BD-802288A11F37 Q28480426-B9D8838E-5452-4612-BC3C-EA062761FF2F Q28480926-332C511E-BE28-4BEF-AA95-67F17BFB029C Q33676809-4C5F6BBB-E92D-4EE1-82DD-FBC25E37FEE2 Q33811937-C02B3DF6-0F9B-4E95-9E7B-6DAC39996E81 Q33932460-7C2F7667-3462-4CD0-A98D-A0BABB818430 Q34010768-4F8D8D9E-0784-4D5B-BA0F-0B1748E9B6C7 Q34074675-2BDA0FA7-0CD0-433A-A292-12131ABD93A1 Q34239225-7BA6C38F-A128-41E0-AF6A-424C45FA50DF Q34278924-24FF6F9F-2714-40D1-AB23-C55F1747621C Q34293391-4F7C3796-5AC4-4946-A03C-BB508E37CE6D Q34300700-A73D00BA-494B-479E-B62E-278E4015DDCE Q34464172-42E30A40-C3D2-4F22-B0DC-C89A1FF9636C Q34668857-F0BC348F-2831-40EF-9488-EC515710F526 Q35111443-13EBB73F-0B69-400D-BD46-A68BC10AFCC9 Q35127284-57B2A1AF-366C-4ED0-A0C4-17E964D70126 Q36276060-FBF5C19B-3D1F-4B7B-8231-4EBDFF7B0415 Q36373227-F47FC679-F4AA-43CB-862C-CD49A82984D4 Q36623076-E38FD3EC-652B-47B5-9076-AFAD7A7F3A5E Q36821373-1305BBB5-C554-4E6D-8C6E-4EFA0D1B5A19 Q37068566-23354515-B820-41B6-843A-59F3947C0391 Q37167047-9BFC7121-FF68-4B52-BBB5-B8111931FBAE Q37237509-BBCC9C55-B769-4C5C-B36C-3E22C267D056 Q37269040-A3339F4F-7FE7-40B9-AF07-07C772A48004 Q37288945-8A46838A-34D7-4D16-80FC-BBDBF41AAEC6 Q37533362-35DB4A78-DF8B-447F-81D5-173989123F68 Q37550614-B5206DFA-FE42-47CE-B032-E3699FBDDC29 Q37986455-F4B97E1B-FDD6-4012-8F91-FABFDF99D5B7 Q38752357-22F7C721-DE50-4739-A512-FB8CC55FB9DE Q38848857-36C18C2B-03A4-4484-9BA1-2979A5448658 Q39019773-2DBA6CC9-D769-45C8-8DCB-C4F4DADFF16E Q39171321-A1733AF6-38F4-4CAC-811F-362F72C76BF2 Q39596870-15B1BD78-B0D9-4FBC-A3C0-2849FC9D4A31 Q39608458-333C5C64-FB57-463F-A6FF-4ABB61000862 Q39619069-FB3365A9-764C-4B8D-A5CF-034EBF183CE2

P2860

Aurora kinases: shining lights on the therapeutic horizon?

http://www.wikidata.org/entity/Q36210257

description

2005 nî lūn-bûn

@nan

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

2005年论文

@zh

2005年论文

@zh-cn

name

Aurora kinases: shining lights on the therapeutic horizon?

@ast

Aurora kinases: shining lights on the therapeutic horizon?

@en

type

label

Aurora kinases: shining lights on the therapeutic horizon?

@ast

Aurora kinases: shining lights on the therapeutic horizon?

@en

prefLabel

Aurora kinases: shining lights on the therapeutic horizon?

@ast

Aurora kinases: shining lights on the therapeutic horizon?

@en

P1433

Q36210257-8E05B605-D191-463B-848E-53DDF54317D2

P1476

Q36210257-FF99B969-DCF9-43D9-B6EA-4AB54EFCA8F7

P2860

Q36210257-0AC5A79E-5E1C-495E-9A40-C9E9B63F5109

Q36210257-28508095-617E-46FC-A54E-8ECD42EF3444

Q36210257-330C8269-EC69-4CE1-816C-A72EAC824918

Q36210257-3391EFD4-69DD-4317-B435-1CC81077CE65

Q36210257-36C86E3F-3979-40E1-A64A-7F03EE08FC51

Q36210257-3F3C4534-ED4D-409B-96F6-70E5E3D6934F

Q36210257-46A3B8AA-F622-4731-93F4-C1C72BF775FA

Q36210257-5F939B93-07BF-4426-B960-761B99591A52

Q36210257-6979C68D-62ED-4FEC-BDF7-B3483D7ADBFC

Q36210257-6F9501BC-B532-416E-9DEF-7963AEDD0426

P2888

Q36210257-D8F205E6-6E12-4646-83BD-512DAA3352EC

P304

Q36210257-5CE2AA94-47B4-466F-BCED-3115532DA517

P31

Q36210257-058936FE-8734-4E3D-8EB8-76EF1C958B5A

P356

Q36210257-192AC9B5-E941-4822-87B0-D113D778F316

P407

Q36210257-696E7766-D506-4F64-9862-A39C43EE85D1

P433

Q36210257-A1441F99-6F06-4FD8-B591-B0F5462DB7B5

P478

Q36210257-318A4C5B-7115-4558-A1E1-7251713F72CD

P50

Q36210257-6A3A745B-8DE8-4365-A36A-123809F1F060

P577

Q36210257-DF064EAC-03A9-4671-ADBA-3A2BB9F02AB3

P5875

Q36210257-66B34EEF-8EAE-4666-AA72-4A11A8D45C75

P698

Q36210257-6ABAD431-912E-4D7C-AD2A-F1B8D99CEFCC

P356

P1433

P1476

Aurora kinases: shining lights on the therapeutic horizon?

@en

P2860

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo

The role of chromosomal instability in tumor initiation.

Cdc20 associates with the kinase aurora2/Aik

Architecture of the budding yeast kinetochore reveals a conserved molecular core

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle

The mechanism of spindle assembly: functions of Ran and its target TPX2

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs

Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation

P2888

P304

5005-5015

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.ONC.1208752

http://www.w3.org/2001/XMLSchema#string

P407

P433

32

http://www.w3.org/2001/XMLSchema#string

P478

24

http://www.w3.org/2001/XMLSchema#string

P50

P577

2005-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7695269

http://www.w3.org/2001/XMLSchema#string

P698

16049526

http://www.w3.org/2001/XMLSchema#string