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Recent advances in the development of Aurora kinases inhibitors in hematological malignanciesFunctions of Aurora kinase C in meiosis and cancerAurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A ReviewAurora kinase A in gastrointestinal cancers: time to targetA Cell Biologist's Field Guide to Aurora Kinase InhibitorsCentrosome - a promising anti-cancer targetAurora kinases as targets in drug-resistant neuroblastoma cellsInhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cellsAurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.A phase I schedule dependency study of the aurora kinase inhibitor MSC1992371A in combination with gemcitabine in patients with solid tumors.Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells.Repositioning: the fast track to new anti-malarial medicines?Aurora kinases: novel therapy targets in cancersThe σ2 receptor: a novel protein for the imaging and treatment of cancer.FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells.A new aurora in anaplastic thyroid cancer therapy.The aurora kinases in cell cycle and leukemiaThe Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidyP21-activated kinase 7 mediates cisplatin-resistance of esophageal squamous carcinoma cells with Aurora-A overexpression.Identification of an Aurora kinase inhibitor specific for the Aurora B isoform.Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinicAlisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cellsInhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells.Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells.A phase 1 dose escalation study of BI 831266, an inhibitor of Aurora kinase B, in patients with advanced solid tumorsExploring a cascade Heck-Suzuki reaction based route to kinase inhibitors using design of experiments.Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA ExpressionABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertibAdvances in small-molecule drug discovery for triple-negative breast cancer.Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer.Novel Aurora/vascular endothelial growth factor receptor dual kinase inhibitor as treatment for hepatocellular carcinoma.RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma.Continuous treatment with FTS confers resistance to apoptosis and affects autophagy.Meta-analysis of gene expression in relapsed childhood B-acute lymphoblastic leukemiaEnhanced construction of gene regulatory networks using hub gene informationDanusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells.Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.Aurora kinase targeting in lung cancer reduces KRAS-induced transformation.
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Aurora kinase inhibitors: progress towards the clinic
@en
Aurora kinase inhibitors: progress towards the clinic.
@nl
type
label
Aurora kinase inhibitors: progress towards the clinic
@en
Aurora kinase inhibitors: progress towards the clinic.
@nl
prefLabel
Aurora kinase inhibitors: progress towards the clinic
@en
Aurora kinase inhibitors: progress towards the clinic.
@nl
P2093
P2860
P50
P1476
Aurora kinase inhibitors: progress towards the clinic
@en
P2093
Daniella Zheleva
Madhu Kollareddy
Pathik Subhashchandra Brahmkshatriya
P2860
P2888
P304
P356
10.1007/S10637-012-9798-6
P577
2012-02-18T00:00:00Z