The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia - Wikidata - wikimedia - TriplyDB

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

http://www.wikidata.org/entity/Q36229601

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The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223 Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?Notch signaling: its roles and therapeutic potential in hematological malignancies Targeting the Notch signaling pathway in cancer therapeutics From fly wings to targeted cancer therapies: a centennial for notch signaling Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors.Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights The role of aberrant proteolysis in lymphomagenesis FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma High accuracy mutation detection in leukemia on a selected panel of cancer genes The canonical Notch signaling pathway: unfolding the activation mechanism.Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes Turn It Down a Notch Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia Mammary development and breast cancer: the role of stem cells IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells.Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma MYC Deregulation in Primary Human Cancers.FBXW7 mutations in melanoma and a new therapeutic paradigm Negative regulation of DAB2IP by Akt and SCFFbw7 pathways Hedgehog signaling is dispensable for adult hematopoietic stem cell function Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia.Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

http://www.wikidata.org/entity/Q36229601

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

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type

label

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

@ast

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

@en

prefLabel

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

@ast

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

@en

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Journal of Experimental Medicine

P1476

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

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P2093

Adolfo Ferrando

http://www.w3.org/2001/XMLSchema#string

Benjamin J Thompson

http://www.w3.org/2001/XMLSchema#string

Iannis Aifantis

http://www.w3.org/2001/XMLSchema#string

Maria Luisa Sulis

http://www.w3.org/2001/XMLSchema#string

Silvia Buonamici

http://www.w3.org/2001/XMLSchema#string

Teresa Palomero

http://www.w3.org/2001/XMLSchema#string

Tomas Vilimas

http://www.w3.org/2001/XMLSchema#string

P2860

Notch1 augments NF-kappaB activity by facilitating its nuclear retention

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

Notch signaling: cell fate control and signal integration in development

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

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1825-1835

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10.1084/JEM.20070872

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8

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204

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17646408

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2118676

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