Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
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Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activityTurning the RING domain protein MdmX into an active ubiquitin-protein ligaseHypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblastsMdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligaseRibosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domainAn essential function of the extreme C-terminus of MDM2 can be provided by MDMXMdmX is a substrate for the deubiquitinating enzyme USP2aMutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stabilityMDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayMdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksTumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signalingSmall molecule compounds targeting the p53 pathway: are we finally making progress?Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerizationMDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to an MDM2-driven inactivation of P53.Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathwayThe Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic TargetSCYL1BP1 modulates neurite outgrowth and regeneration by regulating the Mdm2/p53 pathwaySynergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart developmentModes of p53 regulationp53 pathway is involved in cell competition during mouse embryogenesisMutation analysis of the MDM4 gene in German breast cancer patientsDissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activityEffects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations.The regulation of the p53-mediated stress response by MDM2 and MDM4.Mouse models of p53 functions.p53 is positively regulated by miR-542-3p.Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors.p53-mediated hematopoietic stem and progenitor cell competition.The p53 orchestra: Mdm2 and Mdmx set the tonep53 at a glance.The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.An invertebrate mdm homolog interacts with p53 and is differentially expressed together with p53 and ras in neoplastic Mytilus trossulus haemocytes.Tissue-specific and age-dependent effects of global Mdm2 lossInappropriate p53 activation during development induces features of CHARGE syndrome.Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.The MDM2 gene family.Making sense of ubiquitin ligases that regulate p53.Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer.
P2860
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P2860
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
@ast
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
@en
type
label
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
@ast
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
@en
prefLabel
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
@ast
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
@en
P2093
P356
P1476
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
@en
P2093
P2888
P304
P356
10.1038/SJ.CDD.4401912
P577
2006-06-01T00:00:00Z