Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.
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Neurotransmitter release: the last millisecond in the life of a synaptic vesicleLTP requires a unique postsynaptic SNARE fusion machineryPostsynaptic complexin controls AMPA receptor exocytosis during LTPComplexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helixStructural and mutational analysis of functional differentiation between synaptotagmins-1 and -7Complexins: small but capableThe stressed synapse: the impact of stress and glucocorticoids on glutamate transmissionDistinct initial SNARE configurations underlying the diversity of exocytosisSynaptic vesicles position complexin to block spontaneous fusionComplexin maintains vesicles in the primed state in C. elegansComplexin has opposite effects on two modes of synaptic vesicle fusionCurcumin enhances neurogenesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticityDifferential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia.Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.Accessory alpha-helix of complexin I can displace VAMP2 locally in the complexin-SNARE quaternary complex.Re-examining how complexin inhibits neurotransmitter release.Real-time visualization of complexin during single exocytic events.Membrane curvature sensing by the C-terminal domain of complexin.The accessory helix of complexin functions by stabilizing central helix secondary structureBinding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Re-visiting the trans insertion model for complexin clamping.Molecular underpinnings of synaptic vesicle pool heterogeneity.Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmissionDifferential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexinComplexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complexThe carboxy-terminal domain of complexin I stimulates liposome fusionInteraction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp.Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic stateImmunocytochemical evidence for SNARE protein-dependent transmitter release from guinea pig horizontal cells.N-terminal domain of complexin independently activates calcium-triggered fusion.Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity.C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous NeurotransmissionComplexin splits the membrane-proximal region of a single SNAREpin.Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency.Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.
P2860
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P2860
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Complexins facilitate neurotra ...... malian central nervous system.
@ast
Complexins facilitate neurotra ...... malian central nervous system.
@en
type
label
Complexins facilitate neurotra ...... malian central nervous system.
@ast
Complexins facilitate neurotra ...... malian central nervous system.
@en
prefLabel
Complexins facilitate neurotra ...... malian central nervous system.
@ast
Complexins facilitate neurotra ...... malian central nervous system.
@en
P2093
P2860
P356
P1476
Complexins facilitate neurotra ...... mmalian central nervous system
@en
P2093
Alicja Stradomska
Hongmei Chen
Kerstin Reim
Nils Brose
Weiqi Zhang
P2860
P304
P356
10.1073/PNAS.0803012105
P407
P577
2008-05-27T00:00:00Z