Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.
about
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTENRetinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent MechanismsLTP requires a unique postsynaptic SNARE fusion machineryC-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosisComplexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagminsPostsynaptic complexin controls AMPA receptor exocytosis during LTPComplexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helixComplexins: small but capableSynaptic vesicle recycling: steps and principlesDistinct initial SNARE configurations underlying the diversity of exocytosisComplexin cross-links prefusion SNAREs into a zigzag arrayA conformational switch in complexin is required for synaptotagmin to trigger synaptic fusionComplexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activitySynaptic vesicles position complexin to block spontaneous fusionComplexin maintains vesicles in the primed state in C. elegansComplexin has opposite effects on two modes of synaptic vesicle fusionMolecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretion100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the futureRe-examining how complexin inhibits neurotransmitter release.Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate ComplexinsGenetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivoComplexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanismsLinker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission.Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouseMembrane curvature sensing by the C-terminal domain of complexin.Calcium sensitive ring-like oligomers formed by synaptotagminThe accessory helix of complexin functions by stabilizing central helix secondary structureCauses and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee.Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromesBinding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Transmission, Development, and Plasticity of Synapses.Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexinEvolutionary conservation of complexins: from choanoflagellates to mice.Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity.Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain TissueStabilization of spontaneous neurotransmitter release at ribbon synapses by ribbon-specific subtypes of complexinComplexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complexComplexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic stateN-terminal domain of complexin independently activates calcium-triggered fusion.
P2860
Q24317335-C1BE6F2A-1C92-48CC-9D0C-C62736EC0BEDQ26269820-D84C2A8E-0E7D-4787-9BEC-04BD712EBB88Q26269854-63889003-555A-4F90-BFDC-7A947DBE958BQ26269864-9A1CD9D2-7041-40B4-8CE8-639C03B4B029Q26269866-5FD5C83A-5118-4322-BDC3-8742EDC18AA5Q26269872-D2B59C11-7215-4579-839F-A0ED136DB30EQ26269900-1B4C46E4-9FA1-4128-91F5-D9740944E0EEQ26798363-4C788368-555F-4A51-AEAD-27F48689A621Q26825177-44AFD373-4F38-4CA5-9A62-234B274CADBCQ26866150-2419DF5D-A07F-4287-A1C4-D2C3712F0E4FQ27670976-A8088FD0-EAD0-4F09-BDCC-C474E79DDF07Q28244016-6A8F9840-9B61-483E-89DD-A578CF841FEEQ28281363-F1ECC08A-A846-43DB-98E0-E0EE962942E1Q28284213-083A13D1-7036-4A88-B486-3F7EED460E96Q28302711-20AB55CC-AB7A-4A2E-AC74-835936CC9875Q28302722-BB878667-C1DF-4B36-8CE6-B0D042BEB8E0Q28482128-042BE0D6-E198-4AE0-8633-76E49E44F588Q33615730-2721E2D0-6AF7-4A54-B128-0B4F02D9CD61Q33696042-3B64632A-F21C-4BFF-AD1F-0715E5E73815Q33729393-2A91EFF0-8900-4327-B338-D56CB9FC1E6BQ33925872-809B0E44-BDF2-4118-982D-26C5AE5C6313Q34033326-8FA018F0-2D0C-4ECA-80B5-A46D92FAF2E5Q34069969-62B5AF1D-3535-4BA2-9C89-DF571C986555Q34185958-FA93BD5C-56CD-4BEF-A31C-641C3851A66FQ34269080-01CF1D23-B911-45F9-A56D-9200D7C0A1FFQ34281080-666653C7-27B7-494C-8595-7633233A4714Q34729441-95121CD9-26E5-40A2-9032-0CE62B319DF9Q35008764-F935B560-FE8A-41C8-8152-DCE86FF906D9Q35048620-3D0C8194-65FB-4668-8900-80AC1330E33FQ35210372-56C84FDB-F912-4A09-8A95-A1CFB236F35BQ36132208-F0D9B746-571E-429D-AF00-85A378821D8BQ36137565-8D7E4C81-F8DE-442E-BB69-37213D89F69FQ36518052-88295F04-ACEE-441D-AA4C-5902718A510AQ36615769-5E0315E3-631E-403F-954F-A09B64845AA6Q36844167-EF6FDBC4-8FE8-49DC-8262-646112449267Q36876219-7FAC5E94-446A-46A8-AE30-A57D3C18DBE0Q36959491-44D0A1FD-D6E2-43F0-825A-53B8E2AC5106Q37052763-F5A86492-2B99-4635-809B-5049570EA802Q37078715-6852260E-D4DA-4BEC-92F6-5C1F67BC706BQ37181941-C22E3761-50CF-487D-B60B-53680381FD74
P2860
Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Tilting the balance between fa ...... s synaptic vesicle exocytosis.
@en
Tilting the balance between fa ...... s synaptic vesicle exocytosis.
@nl
type
label
Tilting the balance between fa ...... s synaptic vesicle exocytosis.
@en
Tilting the balance between fa ...... s synaptic vesicle exocytosis.
@nl
prefLabel
Tilting the balance between fa ...... s synaptic vesicle exocytosis.
@en
Tilting the balance between fa ...... s synaptic vesicle exocytosis.
@nl
P2093
P2860
P50
P1433
P1476
Tilting the balance between fa ...... es synaptic vesicle exocytosis
@en
P2093
Hongling Pan
Kerstin Reim
Yong Qi Lin
P2860
P304
P356
10.1016/J.NEURON.2009.09.043
P407
P577
2009-11-01T00:00:00Z