Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells
about
Inhibition of p53 DNA binding by human papillomavirus E6 proteinsIdentification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradationEnhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acidBinding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor proteinViral Mimicry to Usurp Ubiquitin and SUMO Host PathwaysPapillomavirus E6 oncoproteins.Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteinsMultiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cellsHuman papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytesHuman papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligaseThe human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals.Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells.Novel splice variants of cyclin E with altered substrate specificity.The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight formsInactivation of p16 in human mammary epithelial cells by CpG island methylationThe human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damageEnhanced degradation of p53 protein in HPV-6 and BPV-1 E6-immortalized human mammary epithelial cells.Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells.Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer.Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor geneMutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells.Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16.Absence of HPV 16 and 18 DNA in breast cancerMolecular mechanisms of human papillomavirus-induced carcinogenesis.Cellular binding partners of the human papillomavirus E6 protein.Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndromeReversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactionsInhibition of radiation-induced apoptosis by dexamethasone in cervical carcinoma cell lines depends upon increased HPV E6/E7.Loss of p53 protein during radiation transformation of primary human mammary epithelial cells.Transcription of the E6 and E7 genes of human papillomavirus type 6 in anogenital condylomata is restricted to undifferentiated cell layers of the epithelium.Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast CancerEvolution of human papillomavirus carcinogenicity.Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk virusesStaurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent manner
P2860
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P2860
Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Loss of p53 protein in human p ...... human mammary epithelial cells
@en
type
label
Loss of p53 protein in human p ...... human mammary epithelial cells
@en
prefLabel
Loss of p53 protein in human p ...... human mammary epithelial cells
@en
P2093
P2860
P1433
P1476
Loss of p53 protein in human p ...... human mammary epithelial cells
@en
P2093
P2860
P304
P407
P577
1991-12-01T00:00:00Z