Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy.
about
The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationEpilepsy related to developmental tumors and malformations of cortical developmentAutophagy and cancerRecruitment of the oncoprotein v-ErbA to aggresomes.Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)Drugging the addict: non-oncogene addiction as a target for cancer therapyNon-canonical functions of the tuberous sclerosis complex-Rheb signalling axisDeletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivoRecent progress in the study of the Rheb family GTPases.Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.MODULATION OF AUTOPHAGY AND ITS POTENTIAL FOR CANCER THERAPY.Frontier of epilepsy research - mTOR signaling pathway.Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapyComplex inhibitory effects of nitric oxide on autophagyA role for Rac3 GTPase in the regulation of autophagy.Survival by self-destruction: a role for autophagy in the placenta?Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.Lymphangioleiomyomatosis - a wolf in sheep's clothing.Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neuronsRas and rheb signaling in survival and cell deathThe activation sequence of cellular protein handling systems after proteasomal inhibition in dopaminergic cells.Autophagy and tumorigenesisNutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.TSC1/TSC2 signaling in the CNS.mTOR signaling in neural stem cells: from basic biology to disease.mTOR signaling in autophagy regulation in the kidney.Ras and autophagy in cancer development and therapy.Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.Rheb signaling and tumorigenesis: mTORC1 and new horizons.BH3 mimetics activate multiple pro-autophagic pathways.Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells.The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.Specific killing of Rb mutant cancer cells by inactivating TSC2.Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling.The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.To aggregate or not to aggregate? A new role for p62.Lysosomal positioning coordinates cellular nutrient responses.Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1.
P2860
Q24307589-77AF1A25-51A4-4EE1-B45E-168357487663Q26829946-EB48F8C2-14FF-4903-B495-E2FDEDBBDF55Q26865957-20EC7285-F6C7-45FB-95FD-FD51FE9CD065Q27308854-705F6E76-C3AA-4994-B1B4-FE81D64D3221Q27682320-452ADB0D-2022-4264-A9A1-9892BB0D0407Q28079559-C147BC3C-C4CF-4792-9A00-8D137E223AB1Q28728348-99E7DD73-B34E-45E5-9926-776DB805B679Q30529898-E9C6E8B6-760F-4A7F-9E00-7250EA6AC714Q34032753-4697C9BE-DE53-4A5B-96FF-57A6276990CAQ34051183-23E65940-CAEF-45E2-806E-4316723F3C90Q34199557-0F308716-C7FE-45BA-9F3C-B1913A8DAAFAQ34427606-EC0BD8E5-E24D-4FBF-BB33-1BF69B237D93Q34552915-7BB76F8D-3DE2-4C33-B57B-0719E314CCE0Q35014198-EC462E23-0F03-4C6C-ADC7-4829EA465F88Q35107703-8052E785-9498-4E46-AF07-56C76F897821Q35145954-7318A401-EED5-4119-9CD9-A602E27EAFACQ35266447-13B6796C-47E5-44AC-B655-A3A978C61778Q36074298-61A2961D-CB0C-46C9-80D0-AD24EE3B64E8Q36240899-2C371E8A-63B9-49D0-A27E-B4C6033FB1EBQ36357766-780D677A-7300-4928-BCE1-888201CD72FAQ36954995-27320279-3229-4BE5-889B-8A4B68A51A92Q37061781-8AD17AC3-12D4-4521-8783-9A7442158E41Q37200707-21139B26-4D2D-4765-83F2-73D137BDD01EQ37662807-3E1C7DAC-9575-45D2-A8E7-CE4E9D400E71Q37712052-ECC0C8DC-9160-4B58-9742-A6F829C724EBQ37844199-CE26A45A-4241-47FB-814B-6B66344F343EQ38057633-B206FA49-A28A-452A-8EC4-71BF029EEB0CQ38184060-BFE6AFE8-FB2A-45F8-8C63-62E313D3E632Q38192416-4C240686-21A9-480B-9ACA-AF9CD4BC2821Q38447132-11722FDC-8617-4C59-8B37-653CD87E6E69Q38559263-62E7FC08-4D9F-4731-93F9-4753069E3C60Q39565305-C12C687E-4190-46EF-BB41-27F0D981E9C2Q39633655-B8F41C4A-398D-4FEE-A4D9-8919297AC5F3Q39682487-67C7E811-3900-4AB5-A544-B68EF8010FD6Q40669345-FF62ADCF-1558-4981-BE09-555EC42C62A1Q41609951-80683629-1FB7-4A2A-9093-511ADF833B59Q41835967-4395E522-7845-44DE-B429-4D140D2B1810Q42131658-2F882287-F79D-4CF3-8F92-E74F0F318FD1Q42160015-286A58AC-331A-4FCA-96EA-4401A54A6646Q42161815-06384B58-639B-4471-AE07-D2D2F518CF2A
P2860
Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 20 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Rheb controls misfolded protei ...... esome formation and autophagy.
@en
Rheb controls misfolded protei ...... esome formation and autophagy.
@nl
type
label
Rheb controls misfolded protei ...... esome formation and autophagy.
@en
Rheb controls misfolded protei ...... esome formation and autophagy.
@nl
prefLabel
Rheb controls misfolded protei ...... esome formation and autophagy.
@en
Rheb controls misfolded protei ...... esome formation and autophagy.
@nl
P2093
P2860
P356
P1476
Rheb controls misfolded protei ...... esome formation and autophagy.
@en
P2093
Kun-Liang Guan
Tsuneo Ikenoue
Xiaoming Zhou
Xiaowei Chen
P2860
P304
P356
10.1073/PNAS.0903621106
P407
P577
2009-05-20T00:00:00Z