Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice
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Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partnerCloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expressionA novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteinsβ-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapiesInteraction of NF-E2 in the human beta-globin locus control region before chromatin remodelinghMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.A negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic miceAnalysis of the human alpha globin upstream regulatory element (HS-40) in transgenic miceAnalysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the lambda5-VpreB1 locus control region.Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Structural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.Evolution of hemoglobin and its genesSynthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.The beta-globin locus control region versus gene therapy vectors: a struggle for expression.Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell-based gene therapy.Evaluation of beta-globin gene therapy constructs in single copy transgenic mice.The 5' flanking region of the rat LAP (C/EBP beta) gene can direct high-level, position-independent, copy number-dependent expression in multiple tissues in transgenic mice.Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expressionRetroviral vector sequences inhibit human beta-globin gene expression in transgenic mice.Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences.Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.Studying the recruitment of Sp1 to the beta-globin promoter with an in vivo method: protein position identification with nuclease tail (PIN*POINT)A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.Structure and function of the murine beta-globin locus control region 5' HS-3.Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase.LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.Essential role of NF-E2 in remodeling of chromatin structure and transcriptional activation of the epsilon-globin gene in vivo by 5' hypersensitive site 2 of the beta-globin locus control regionDissecting a locus control region: facilitation of enhancer function by extended enhancer-flanking sequences.Position effect variegation and imprinting of transgenes in lymphocytesEnhancer-dependent transcription of the epsilon-globin promoter requires promoter-bound GATA-1 and enhancer-bound AP-1/NF-E2Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.Transcriptional activation of human zeta 2 globin promoter by the alpha globin regulatory element (HS-40): functional role of specific nuclear factor-DNA complexes.An enhancer/locus control region is not sufficient to open chromatin.A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression.Regulated expression of the human beta globin gene in transgenic mice requires an upstream globin or nonglobin promoter.
P2860
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P2860
Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Human beta-globin locus contro ...... e site HS 2 in transgenic mice
@en
Human beta-globin locus contro ...... site HS 2 in transgenic mice.
@nl
type
label
Human beta-globin locus contro ...... e site HS 2 in transgenic mice
@en
Human beta-globin locus contro ...... site HS 2 in transgenic mice.
@nl
prefLabel
Human beta-globin locus contro ...... e site HS 2 in transgenic mice
@en
Human beta-globin locus contro ...... site HS 2 in transgenic mice.
@nl
P2093
P2860
P356
P1476
Human beta-globin locus contro ...... e site HS 2 in transgenic mice
@en
P2093
J J Caterina
K M Pawlik
R D Palmiter
R L Brinster
R R Behringer
T M Townes
P2860
P304
P356
10.1073/PNAS.88.5.1626
P407
P577
1991-03-01T00:00:00Z