Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia.
about
PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53The RUNX genes: gain or loss of function in cancerMeiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient miceMolecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland.NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis.Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice.An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis.The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cellsCancer gene discovery in mouse and man.Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia.Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines.CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymusKIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11.Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice.An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML.The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models.Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia.Substitution of feline leukemia virus long terminal repeat sequences into murine leukemia virus alters the pattern of insertional activation and identifies new common insertion sitesA novel oncoprotein Pirh2: rising from the shadow of MDM2.Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer.Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups.Mouse models for core binding factor leukemia.Importance of receptor usage, Fli1 activation, and mouse strain for the stem cell specificity of 10A1 murine leukemia virus leukemogenicity.Modulation of PLAGL2 transactivation by positive cofactor 2 (PC2), a component of the ARC/Mediator complex.Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2.Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation.CBFB-MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia.CHD7 deficiency delays leukemogenesis in mice induced by CBFB-MYH11.The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation.
P2860
Q24650929-9EE7853C-9E31-4F84-98B3-81D107D05822Q28247901-BFAF4AF4-6370-4069-8BBE-BCD31B975CFAQ28588914-550D6AEA-1EF7-45F9-8C6C-80939D32B4F1Q30252938-401C3BB3-0EED-4FAA-B0BC-2B3A14FE62CCQ30300790-FC8F6384-465C-4637-AFAB-A7C50EE95AE3Q30432285-CCC6745F-592B-4241-8172-3DAD81A67C3FQ33555996-C94ADDFB-BA9C-4ADC-B3D7-8559AAD75BD3Q33917204-441A8FF2-06D6-48DF-BF8A-395B2FE4DA0FQ34024277-2454580F-5BB5-4ABE-9005-86854B67F65DQ34171480-EB6C09A3-7213-475D-ABAE-F92DE9C91406Q34792228-D24CB2FB-0A59-41F5-947E-C5E0A5FD80D8Q34962407-965262CA-2D05-421C-86C9-5E64986CE0FBQ35055356-1DD192A6-92AF-4141-BF79-ECAF48A3F64DQ35139632-F1B3E30E-CE4D-48D4-A4E0-AB252CB83429Q35751063-E90C3A12-17E5-430B-9D6E-F1B981775176Q35776437-37929ACE-C7DD-4EEA-9D75-C6AAFE941D9AQ35779737-337C85B4-BBE1-4125-892D-D15CEDA1D20EQ35920680-0CA604F2-3C5C-4777-807D-019ABEA79251Q35995227-AAB25D60-F308-403B-941F-792EE0BC484BQ36233848-0ED9534F-8976-4B37-919C-8DC95687B898Q36309953-B7176AAC-61AB-4DE6-B089-C8814EEAE41FQ36407189-B5B1BC15-041E-47DC-B5F0-F71F5EC15C2AQ36407239-2667CD91-C579-4870-8207-492F09E8E3A6Q36843787-5A351F6D-776E-4AF6-BAC3-34DF69A3EFEBQ37151181-73916359-FB5A-4894-B217-782DE355F778Q37662400-082F15DB-32D4-446A-8F91-1AAEC0A49802Q37747920-C8787EDF-E66A-4F13-85AC-F0ECE4695068Q37834073-253441A1-8F37-4EA9-AB8B-2B8AA5F3D9ECQ38288838-3E59D4BE-9D2E-4BFE-942C-9924002C70D3Q38298230-69F00C64-4AF4-49F9-BC9B-E8C5E63C1C92Q38333998-47466BC9-343A-4C48-9010-0A965F2FB1FAQ38545496-8E4EE807-D586-49F9-8D07-5D47D6E0B731Q39403641-11FD6BA8-B138-4D00-86A2-7449736E7D27Q39760686-5D09FABA-0FF0-44C7-B092-A47DB9BD8179Q40365095-222F0217-89D4-452C-8F7E-4877D5A9BF8FQ42185555-47CE908F-2691-43B1-87DF-B189299B0039Q42444092-4DEEF4AE-25D6-45CE-9B0A-A407ED9BC0E7Q42778080-F4BFAC0A-D1CE-4F94-9D6A-097A6A1AA754Q42809646-7294D351-BBF7-493B-9E12-9856B231B0DFQ47857157-DA45EC42-2305-4CC6-BE83-C99BACC28029
P2860
Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 March 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Identification of genes that s ...... sis of acute myeloid leukemia.
@en
Identification of genes that s ...... sis of acute myeloid leukemia.
@nl
type
label
Identification of genes that s ...... sis of acute myeloid leukemia.
@en
Identification of genes that s ...... sis of acute myeloid leukemia.
@nl
prefLabel
Identification of genes that s ...... sis of acute myeloid leukemia.
@en
Identification of genes that s ...... sis of acute myeloid leukemia.
@nl
P2093
P2860
P356
P1476
Identification of genes that s ...... sis of acute myeloid leukemia.
@en
P2093
J Flanegan
L H Castilla
N J Martinez
P2860
P304
P356
10.1073/PNAS.0400930101
P407
P577
2004-03-24T00:00:00Z