The v-rel oncogene: insights into the mechanism of transcriptional activation, repression, and transformation.
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A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerizationMutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformationAn isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcriptionBoth N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motifOHMM: a Hidden Markov Model accurately predicting the occupancy of a transcription factor with a self-overlapping binding motif.AP-1 factors play an important role in transformation induced by the v-rel oncogene.Mapping of a serine-rich domain essential for the transcriptional, antiapoptotic, and transforming activities of the v-Rel oncoprotein.Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered kappa B DNA-binding complexes in transformed cellsThe c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus.v-rel Induces ectopic expression of an adhesion molecule, DM-GRASP, during B-lymphoma developmentInteraction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel.Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformationTransformation of avian fibroblasts overexpressing the c-rel proto-oncogene and a variant of c-rel lacking 40 C-terminal amino acids.In vivo evolution of c-rel oncogenic potential.MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.The bZIP transactivator of Epstein-Barr virus, BZLF1, functionally and physically interacts with the p65 subunit of NF-kappa BTemperature-sensitive transforming mutants of the v-rel oncogene.Heterologous C-terminal sequences disrupt transcriptional activation and oncogenesis by p59v-rel.NF-kappa B p100 is one of the high-molecular-weight proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells.Differential pp40I kappa B-beta inhibition of DNA binding by rel proteinsFunctional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interactionFunctional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB.A mutant v-rel with increased ability to transform B lymphocytes.The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice.PEST-dependent cytoplasmic retention of v-Rel by I(kappa)B-alpha: evidence that I(kappa)B-alpha regulates cellular localization of c-Rel and v-Rel by distinct mechanisms.The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice.
P2860
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P2860
The v-rel oncogene: insights into the mechanism of transcriptional activation, repression, and transformation.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
The v-rel oncogene: insights i ...... epression, and transformation.
@en
type
label
The v-rel oncogene: insights i ...... epression, and transformation.
@en
prefLabel
The v-rel oncogene: insights i ...... epression, and transformation.
@en
P2093
P2860
P1433
P1476
The v-rel oncogene: insights i ...... epression, and transformation.
@en
P2093
Ballard DW
Hoffman JA
Kaufman PA
P2860
P304
P407
P577
1992-08-01T00:00:00Z