The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step
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The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2A functional analysis of the spacer of V(D)J recombination signal sequencesStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisHMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their endsComputational analysis and determination of a highly conserved surface exposed segment in H5N1 avian flu and H1N1 swine flu neuraminidaseElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingThermal dependency of RAG1 self-association properties.Transposition mediated by RAG1 and RAG2 and the evolution of the adaptive immune system.HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombinationConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.Ordered assembly of the V(D)J synaptic complex ensures accurate recombinationThe RAG proteins in V(D)J recombination: more than just a nuclease.A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals.Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksHuman severe combined immune deficiency and DNA repair.The bounty of RAGs: recombination signal complexes and reaction outcomes.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.Quantitative analyses of RAG-RSS interactions and conformations revealed by atomic force microscopy.A non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2An activation-induced cytidine deaminase-independent mechanism of secondary VH gene rearrangement in preimmune human B cellsInitial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.Real-time analysis of RAG complex activity in V(D)J recombinationA zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity.Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination.Gene therapy vectors: the prospects and potentials of the cut-and-paste transposons.The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoireAsymmetric processing of human immunodeficiency virus type 1 cDNA in vivo: implications for functional end coupling during the chemical steps of DNA transposition.A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination.RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule.Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule.Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoire.Immunoglobulin genes undergo legitimate repair in human B cells not only after cis- but also frequent trans-class switch recombination.
P2860
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P2860
The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The RAG-HMG1 complex enforces ...... double-hairpin formation step
@en
type
label
The RAG-HMG1 complex enforces ...... double-hairpin formation step
@en
prefLabel
The RAG-HMG1 complex enforces ...... double-hairpin formation step
@en
P2860
P356
P1476
The RAG-HMG1 complex enforces ...... double-hairpin formation step
@en
P2093
P2860
P304
P356
10.1128/MCB.18.11.6408
P407
P577
1998-11-01T00:00:00Z