Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.
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Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrestRapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding elementA comprehensive pathway map of epidermal growth factor receptor signalingTransforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancerHER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cellsMechanistic basis and clinical relevance of the role of transforming growth factor-β in cancerThe role of MIZ-1 in MYC-dependent tumorigenesisBoth Max and TFE3 cooperate with Smad proteins to bind the plasminogen activator inhibitor-1 promoter, but they have opposite effects on transcriptional activityInhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genesThe myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factorsOncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesisPremature senescence and increased TGFβ signaling in the absence of Tgif1.Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1.Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction.The regulation of TGF-β/SMAD signaling by protein deubiquitination.Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization.Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells.Smad2 overexpression reduces the proliferation of the junctional epithelium.The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3.Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma.TGF-beta flips the Myc switch.Cell cycle control genes and hematopoietic cell differentiation.Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program.SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).Early growth response-2 expression in uterine leiomyoma cells: regulation and functionSignal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: in vitro and in vivo studiesA role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrestTransforming growth factor-beta signaling in normal and malignant hematopoiesis.Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.The intracellular form of notch blocks transforming growth factor beta-mediated growth arrest in Mv1Lu epithelial cells.Abrogation of transforming growth factor-beta signaling in pancreatic cancer.Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activityDown-regulation of transforming growth factor-beta type II receptor (TGF-betaRII) protein and mRNA expression in cervical cancer.
P2860
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P2860
Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Myc downregulation by transforming growth factor beta required for activation of the p15
@nl
Myc downregulation by transfor ...... 15(Ink4b) G(1) arrest pathway.
@en
type
label
Myc downregulation by transforming growth factor beta required for activation of the p15
@nl
Myc downregulation by transfor ...... 15(Ink4b) G(1) arrest pathway.
@en
prefLabel
Myc downregulation by transforming growth factor beta required for activation of the p15
@nl
Myc downregulation by transfor ...... 15(Ink4b) G(1) arrest pathway.
@en
P2860
P356
P1476
Myc downregulation by transfor ...... p15(Ink4b) G(1) arrest pathway
@en
P2093
P2860
P304
P356
10.1128/MCB.19.9.5913
P407
P577
1999-09-01T00:00:00Z