Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway.
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A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancersThe p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in miceRepression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNAThe RUNX genes: gain or loss of function in cancerAkt promotes BMP2-mediated osteoblast differentiation and bone developmentFoxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblastsEGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation.Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription.c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.Gastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanismsO-GlcNAc modification of the runt-related transcription factor 2 (Runx2) links osteogenesis and nutrient metabolism in bone marrow mesenchymal stem cells.Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motilityFOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasionRedox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcriptionPhysical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression.Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner.Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal developmentA Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy.GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression.Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer CellsHyperglycemia regulates RUNX2 activation and cellular wound healing through the aldose reductase polyol pathway.The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma.Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-κB signalingPost-translational Regulation of Runx2 in Bone and Cartilage.Serum response factor regulates bone formation via IGF-1 and Runx2 signals.p21-Activated protein kinases and their emerging roles in glucose homeostasis.Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity.Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation.Twist as a new prognostic marker in hematological malignancies.Covalent Modifications of RUNX Proteins: Structure Affects Function.Regulation of Bone Metabolism.P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine.Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin.Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation.Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells.Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition.
P2860
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P2860
Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Insulin-like growth factor-1 r ...... independent signaling pathway.
@en
type
label
Insulin-like growth factor-1 r ...... independent signaling pathway.
@en
prefLabel
Insulin-like growth factor-1 r ...... independent signaling pathway.
@en
P2093
P2860
P356
P1476
Insulin-like growth factor-1 r ...... independent signaling pathway.
@en
P2093
Antonino Passaniti
Paul Shapiro
Rakesh Kumar
P2860
P304
42709-42718
P356
10.1074/JBC.M404480200
P407
P577
2004-08-09T00:00:00Z