PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy.
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Pim1 inhibition as a novel therapeutic strategy for Alzheimer's diseaseTGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansionDPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese ratmicroRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasionHigh glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression.Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes.TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression.High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression.Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells.Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy.Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy.MicroRNA-214 Reduces Insulin-like Growth Factor-1 (IGF-1) Receptor Expression and Downstream mTORC1 Signaling in Renal Carcinoma Cells.Src tyrosine kinase mediates platelet-derived growth factor BB-induced and redox-dependent migration in metanephric mesenchymal cells.Role of PRAS40 in Akt and mTOR signaling in health and disease.In vitro and in vivo inhibition of mTOR by 1,25-dihydroxyvitamin D3 to improve early diabetic nephropathy via the DDIT4/TSC2/mTOR pathway.Long non-coding RNA ENSMUST00000147869 protects mesangial cells from proliferation and fibrosis induced by diabetic nephropathy.TGFβ enforces activation of eukaryotic elongation factor-2 (eEF2) via inactivation of eEF2 kinase by p90 ribosomal S6 kinase (p90Rsk) to induce mesangial cell hypertrophy.High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophyPRAS40 promotes NF-κB transcriptional activity through association with p65.PRAS40 signaling in tumor.Phosphorylation of PRAS40-Thr246 involved in renal lipid accumulation of diabetes.Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin.Tyrosines-740/751 of PDGFRβ contribute to the activation of Akt/Hif1α/TGFβ nexus to drive high glucose-induced glomerular mesangial cell hypertrophy.Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion.PDGF receptor-β uses Akt/mTORC1 signaling node to promote high glucose-induced renal proximal tubular cell collagen I (α2) expression.microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression.Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle.
P2860
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P2860
PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy.
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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2010年學術文章
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2010年學術文章
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name
PRAS40 acts as a nodal regulat ...... ar mesangial cell hypertrophy.
@en
PRAS40 acts as a nodal regulat ...... ar mesangial cell hypertrophy.
@nl
type
label
PRAS40 acts as a nodal regulat ...... ar mesangial cell hypertrophy.
@en
PRAS40 acts as a nodal regulat ...... ar mesangial cell hypertrophy.
@nl
prefLabel
PRAS40 acts as a nodal regulat ...... ar mesangial cell hypertrophy.
@en
PRAS40 acts as a nodal regulat ...... ar mesangial cell hypertrophy.
@nl
P2093
P2860
P356
P1476
PRAS40 acts as a nodal regulat ...... ar mesangial cell hypertrophy.
@en
P2093
Balachandar Venkatesan
Balakuntalam S Kasinath
Falguni Das
Goutam Ghosh Choudhury
Jeffrey L Barnes
Nandini Ghosh-Choudhury
Nirmalya Dey
Xiaonan Li
P2860
P356
10.1002/JCP.22186
P577
2010-10-01T00:00:00Z