Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+.
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Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialDesign of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsMn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondriaA combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itselfPharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 miceImpact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumorTexaphyrins: tumor localizing redox active expanded porphyrinsManganese superoxide dismutase, MnSOD and its mimicsDesign, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-Tumorigenic?Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide.Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activityQuality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes.Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: voltammetric and chronocoulometric study of protolytic and redox equilibria.Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+).Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion.New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.Unconventional neuroprotection against Ca2+ -dependent insults by metalloporphyrin catalytic antioxidants.
P2860
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P2860
Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Electrostatic contribution in ...... PyP5+ versus MnIIIBr8T-2-PyP+.
@en
Electrostatic contribution in ...... PyP5+ versus MnIIIBr8T-2-PyP+.
@nl
type
label
Electrostatic contribution in ...... PyP5+ versus MnIIIBr8T-2-PyP+.
@en
Electrostatic contribution in ...... PyP5+ versus MnIIIBr8T-2-PyP+.
@nl
prefLabel
Electrostatic contribution in ...... PyP5+ versus MnIIIBr8T-2-PyP+.
@en
Electrostatic contribution in ...... PyP5+ versus MnIIIBr8T-2-PyP+.
@nl
P2093
P2860
P356
P1476
Electrostatic contribution in ...... PyP5+ versus MnIIIBr8T-2-PyP+.
@en
P2093
Ines Batinic-Haberle
Irwin Fridovich
Ivan Spasojevic
Julio S Reboucas
Ynara Marina Idemori
P2860
P304
P356
10.1074/JBC.M211346200
P407
P577
2002-12-09T00:00:00Z