Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes.
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The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignanciesSOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysMn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathwaysNovel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents.Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhageSuperoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialRational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsAn educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.Comparative Study on the Efficiency of the Photodynamic Inactivation of Candida albicans Using CdTe Quantum Dots, Zn(II) Porphyrin and Their Conjugates as Photosensitizers.A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins.Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.Cardiac oxidative stress in a mouse model of neutral lipid storage disease.Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.Simple biological systems for assessing the activity of superoxide dismutase mimics.Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coliDetermination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics.Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+).Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.
P2860
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P2860
Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Quality of potent Mn porphyrin ...... hanistic/therapeutic purposes.
@en
type
label
Quality of potent Mn porphyrin ...... hanistic/therapeutic purposes.
@en
prefLabel
Quality of potent Mn porphyrin ...... hanistic/therapeutic purposes.
@en
P2093
P2860
P1476
Quality of potent Mn porphyrin ...... hanistic/therapeutic purposes.
@en
P2093
Ines Batinić-Haberle
Ivan Spasojević
Júlio S Rebouças
P2860
P304
P356
10.1016/J.JPBA.2008.08.005
P577
2008-08-14T00:00:00Z