High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
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High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samplesIn vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AMLBone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosisImmunohistochemical detection of Ym1/Ym2 chitinase-like lectins associated with hyalinosis and polypoid adenomas of the transitional epithelium in a mouse with acute myeloid leukemiaMll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemiasGenomic and epigenomic landscapes of adult de novo acute myeloid leukemia.Diagnostic exercise: sudden death in a mouse with experimentally induced acute myeloid leukemia.Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.Long FLT3 internal tandem duplications and reduced PML-RARα expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patients.Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL.Pharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effect.A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemiaExpression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA micePML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progressionSTAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AMLVCre/VloxP and SCre/SloxP: new site-specific recombination systems for genome engineering.Establishment of a humanized APL model via the transplantation of PML-RARA-transduced human common myeloid progenitors into immunodeficient mice.A truncation mutant of Csf3r cooperates with PML-RARα to induce acute myeloid leukemia in mice.Acute promyelocytic leukemia: where does it stem from?A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine LeukemogenesisAltered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemiaEffect of transcription-factor concentrations on leukemic stem cells.Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia.Fusion-protein truncation provides new insights into leukemogenesis.Animal models of acute myelogenous leukaemia - development, application and future perspectives.Misfolded N-CoR is Linked to the Ectopic Reactivation of CD34/Flt3-Based Stem-Cell Phenotype in Promyelocytic and Monocytic Acute Myeloid LeukemiaTreatment-influenced associations of PML-RARα mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia.The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells.Clinical outcome of patients with acute promyelocytic leukemia and FLT3 mutationsPML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.PML(NLS(-)) inhibits cell apoptosis and promotes proliferation in HL-60 cells.Review: genetic models of acute myeloid leukaemia.Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL.Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.
P2860
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P2860
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
High-penetrance mouse model of ...... ls of PML-RARalpha expression.
@en
High-penetrance mouse model of ...... ls of PML-RARalpha expression.
@nl
type
label
High-penetrance mouse model of ...... ls of PML-RARalpha expression.
@en
High-penetrance mouse model of ...... ls of PML-RARalpha expression.
@nl
prefLabel
High-penetrance mouse model of ...... ls of PML-RARalpha expression.
@en
High-penetrance mouse model of ...... ls of PML-RARalpha expression.
@nl
P2093
P1433
P1476
High-penetrance mouse model of ...... ls of PML-RARalpha expression.
@en
P2093
Andrew A Lane
Drazen B Zimonjic
Jessica L Pollock
John F DiPersio
Kristie Oldfather
Matthew S Holt
Nicholas C Popescu
Peter Westervelt
Timothy J Ley
P304
P356
10.1182/BLOOD-2002-12-3779
P407
P577
2003-05-15T00:00:00Z