Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution.
about
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysMetal complexes as potential modulators of inflammatory and autoimmune responses.Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialDiverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsSOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itselfPharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 miceImpact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumorSimple biological systems for assessing the activity of superoxide dismutase mimics.Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Catalytic antioxidant therapy by metallodrugs: lessons from metallocorroles.Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide.Orally available Mn porphyrins with superoxide dismutase and catalase activities.Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes.Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate.High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coliDetermination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics.Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+).
P2860
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P2860
Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Redox modulation of oxidative ...... effect of charge distribution.
@en
Redox modulation of oxidative ...... effect of charge distribution.
@nl
type
label
Redox modulation of oxidative ...... effect of charge distribution.
@en
Redox modulation of oxidative ...... effect of charge distribution.
@nl
prefLabel
Redox modulation of oxidative ...... effect of charge distribution.
@en
Redox modulation of oxidative ...... effect of charge distribution.
@nl
P2093
P2860
P50
P356
P1433
P1476
Redox modulation of oxidative ...... effect of charge distribution
@en
P2093
Arlette Richaud
Francisco Méndez
Ines Batinić-Haberle
Ivan Spasojević
P2860
P304
P356
10.1039/B716517J
P407
P577
2008-01-07T00:00:00Z