Human Rad50/Mre11 is a flexible complex that can tether DNA ends
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Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringComposition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complexRad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaksSynapsis of DNA ends by DNA-dependent protein kinaseThe transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repairDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsDNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcaniiDNA end resection: many nucleases make light workBacillus subtilis RecN binds and protects 3'-single-stranded DNA extensions in the presence of ATP.Mre11 assembles linear DNA fragments into DNA damage signaling complexesSaccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNADNA End Resection: Facts and MechanismsDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeIgH chain class switch recombination: mechanism and regulationThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesDNA dynamics during early double-strand break processing revealed by non-intrusive imaging of living cellsStructural conservation of RecF and Rad50: implications for DNA recognition and RecF functionCrystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA RepairMre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break RepairThe Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break RepairATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingYeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends.Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairHinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA.RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?Non-homologous end-joining, a sticky affairMCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complexRelative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell linesRad50 is dispensable for the maintenance and viability of postmitotic tissuesTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksCharacteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiationNibrin functions in Ig class-switch recombination
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P2860
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
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2001 nî lūn-bûn
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2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@ast
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@en
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
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type
label
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@ast
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@en
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@nl
prefLabel
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@ast
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@en
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@nl
P2093
P3181
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P1476
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
@en
P2093
P304
P3181
P356
10.1016/S1097-2765(01)00381-1
P407
P50
P577
2001-11-01T00:00:00Z