Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids
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Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoterAn embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimerCloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expressionIsolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control regionHemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific proteinDeletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasiaCurrent and future alternative therapies for beta-thalassemia majorFetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathiesExploiting genomics and natural genetic variation to decode macrophage enhancersUsing the ENCODE Resource for Functional Annotation of Genetic VariantsThe human beta-globin locus control regionhMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2Nrf2 is essential for protection against acute pulmonary injury in miceQuantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse beta-globin LCRAn important function of Nrf2 in combating oxidative stress: detoxification of acetaminophenNRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and developmentEffect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.Genome-wide epigenetic data facilitate understanding of disease susceptibility association studies.Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator.Chromatin structures of the rat tyrosine aminotransferase gene relate to the function of its cis-acting elements.High-level beta-globin expression after retroviral transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells.Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control regionIn vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region.Expression of human alpha-globin and mouse/human hybrid beta-globin genes in murine hemopoietic stem cells transduced by recombinant retroviruses.Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice.Control of globin gene expression during development and erythroid differentiationAsynchronous DNA replication within the human beta-globin gene locus.Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionThe locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Molecular determinants of NOTCH4 transcription in vascular endothelium.Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.High-level erythroid expression of human alpha-globin genes in transgenic mice.An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.Gene therapy for the hemoglobin disorders: past, present, and future.Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster
P2860
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P2860
Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Evidence for a locus activatio ...... s in globin-expressing hybrids
@ast
Evidence for a locus activatio ...... s in globin-expressing hybrids
@en
type
label
Evidence for a locus activatio ...... s in globin-expressing hybrids
@ast
Evidence for a locus activatio ...... s in globin-expressing hybrids
@en
prefLabel
Evidence for a locus activatio ...... s in globin-expressing hybrids
@ast
Evidence for a locus activatio ...... s in globin-expressing hybrids
@en
P2093
P2860
P356
P1476
Evidence for a locus activatio ...... s in globin-expressing hybrids
@en
P2093
G Stamatoyannopoulos
M Groudine
S Takegawa
T Papayannopoulou
W C Forrester
P2860
P304
10159-10177
P356
10.1093/NAR/15.24.10159
P407
P577
1987-12-01T00:00:00Z