Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. - Wikidata - awgldk - TriplyDB

Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.

Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.

http://www.wikidata.org/entity/Q37264051

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SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73 The role of aneuploidy in promoting and suppressing tumors New Auroras on the Roles of the Chromosomal Passenger Complex in Cytokinesis: Implications for Cancer Therapies Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo Cycles and the qualitative evolution of chemical systems Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.Cdc20 and securin overexpression predict short-term breast cancer survival.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.BRAF inactivation drives aneuploidy by deregulating CRAF RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts.Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast.Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells.Mutual regulation between the spindle checkpoint and APC/C.DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway.Losing balance: the origin and impact of aneuploidy in cancer Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.Identification of aneuploidy-selective antiproliferation compounds.Aneuploidy causes proteotoxic stress in yeast Aneuploidy in health, disease, and aging.Aneuploidy and tumorigenesis.Spindle assembly checkpoint, aneuploidy and tumorigenesis.High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.Mechanisms of chromosomal instability.The spindle assembly checkpoint: More than just keeping track of the spindle.A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.New insights into the troubles of aneuploidy Learning about cancer from frogs: analysis of mitotic spindles in Xenopus egg extracts.Chromosomal instability and aneuploidy in cancer: from yeast to man Genetic instability: tipping the balance.The cancer biology of whole-chromosome instability.Gene copy-number alterations: a cost-benefit analysis.β-catenin at the centrosome: discrete pools of β-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression.

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Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.

http://www.wikidata.org/entity/Q37264051

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on June 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Loss of spindle assembly check ...... romotes tumorigenesis in mice.

@en

Loss of spindle assembly check ...... romotes tumorigenesis in mice.

@nl

type

label

Loss of spindle assembly check ...... romotes tumorigenesis in mice.

@en

Loss of spindle assembly check ...... romotes tumorigenesis in mice.

@nl

prefLabel

Loss of spindle assembly check ...... romotes tumorigenesis in mice.

@en

Loss of spindle assembly check ...... romotes tumorigenesis in mice.

@nl

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Journal of Cell Biology

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Loss of spindle assembly check ...... romotes tumorigenesis in mice.

@en

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J Philippe York

http://www.w3.org/2001/XMLSchema#string

Min Li

http://www.w3.org/2001/XMLSchema#string

Pumin Zhang

http://www.w3.org/2001/XMLSchema#string

Xiao Fang

http://www.w3.org/2001/XMLSchema#string

Zhubo Wei

http://www.w3.org/2001/XMLSchema#string

P2860

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

Mutations of mitotic checkpoint genes in human cancers

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation

Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

The age distribution of cancer and a multi-stage theory of carcinogenesis

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast.

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983-994

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scholarly article

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10.1083/JCB.200904020

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6

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185

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2009-06-01T00:00:00Z

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26293814

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19528295

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2711613

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