Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.
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SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activityAurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73The role of aneuploidy in promoting and suppressing tumorsNew Auroras on the Roles of the Chromosomal Passenger Complex in Cytokinesis: Implications for Cancer TherapiesExcess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivoCycles and the qualitative evolution of chemical systemsDeletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.Cdc20 and securin overexpression predict short-term breast cancer survival.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesisCdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.BRAF inactivation drives aneuploidy by deregulating CRAFRABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts.Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast.Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells.Mutual regulation between the spindle checkpoint and APC/C.DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway.Losing balance: the origin and impact of aneuploidy in cancerBub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.Identification of aneuploidy-selective antiproliferation compounds.Aneuploidy causes proteotoxic stress in yeastAneuploidy in health, disease, and aging.Aneuploidy and tumorigenesis.Spindle assembly checkpoint, aneuploidy and tumorigenesis.High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.Mechanisms of chromosomal instability.The spindle assembly checkpoint: More than just keeping track of the spindle.A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosisPttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.New insights into the troubles of aneuploidyLearning about cancer from frogs: analysis of mitotic spindles in Xenopus egg extracts.Chromosomal instability and aneuploidy in cancer: from yeast to manGenetic instability: tipping the balance.The cancer biology of whole-chromosome instability.Gene copy-number alterations: a cost-benefit analysis.β-catenin at the centrosome: discrete pools of β-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression.
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Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Loss of spindle assembly check ...... romotes tumorigenesis in mice.
@en
Loss of spindle assembly check ...... romotes tumorigenesis in mice.
@nl
type
label
Loss of spindle assembly check ...... romotes tumorigenesis in mice.
@en
Loss of spindle assembly check ...... romotes tumorigenesis in mice.
@nl
prefLabel
Loss of spindle assembly check ...... romotes tumorigenesis in mice.
@en
Loss of spindle assembly check ...... romotes tumorigenesis in mice.
@nl
P2093
P2860
P356
P1476
Loss of spindle assembly check ...... romotes tumorigenesis in mice.
@en
P2093
J Philippe York
Pumin Zhang
P2860
P304
P356
10.1083/JCB.200904020
P407
P577
2009-06-01T00:00:00Z