MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts
about
BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisionsMito-priming as a method to engineer Bcl-2 addiction.A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2.BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells.An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737.Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapyRapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.Inhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance.Examination of a second node of translational control in the unfolded protein response.Mitochondria: gatekeepers of response to chemotherapyImpact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemiaComplementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cellsThe role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy.Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Evading apoptosis in cancer.Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabineBiphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cellsUrocortin-2 suppression of p38-MAPK signaling as an additional mechanism for ischemic cardioprotection.Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer cells and enhances the therapeutic efficacy of BH3 mimeticsKnockdown of CD44 enhances chemosensitivity of acute myeloid leukemia cells to ADM and Ara-C.BH3 profiling in whole cells by fluorimeter or FACSRelative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AMLBCL2 suppresses PARP1 function and nonapoptotic cell death.Purported Mcl-1 inhibitor marinopyrrole A fails to show selective cytotoxicity for Mcl-1-dependent cell lines.Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling.
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MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 26 October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
MCL-1-dependent leukemia cells ...... n BCL-2-dependent counterparts
@en
MCL-1-dependent leukemia cells ...... BCL-2-dependent counterparts.
@nl
type
label
MCL-1-dependent leukemia cells ...... n BCL-2-dependent counterparts
@en
MCL-1-dependent leukemia cells ...... BCL-2-dependent counterparts.
@nl
prefLabel
MCL-1-dependent leukemia cells ...... n BCL-2-dependent counterparts
@en
MCL-1-dependent leukemia cells ...... BCL-2-dependent counterparts.
@nl
P2093
P2860
P356
P1476
MCL-1-dependent leukemia cells ...... n BCL-2-dependent counterparts
@en
P2093
Anthony Letai
Derek Yecies
Jeremy Ryan
Joseph T Opferman
Joslyn K Brunelle
P2860
P304
P356
10.1083/JCB.200904049
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P577
2009-10-26T00:00:00Z