The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge.
about
Influence of permeant ions on voltage sensor function in the Kv2.1 potassium channelThe pharmacology of cyclic nucleotide-gated channels: emerging from the darknessVoltage gated ion channel function: gating, conduction, and the role of water and protonsPrinciples and properties of ion flow in P2X receptorsModeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cyclesThe gate of the influenza virus M2 proton channel is formed by a single tryptophan residueResidue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels.Preventing voltage-dependent gating of anthrax toxin channels using engineered disulfides.Design and characterization of a constitutively open KcsA.Models of the structure and voltage-gating mechanism of the shaker K+ channel.Monte Carlo-energy minimization of correolide in the Kv1.3 channel: possible role of potassium ion in ligand-receptor interactions.Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channelsModulation of the ERG K+ current by the tyrosine phosphatase, SHP-1.Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel.Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channelsResidues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.Movement of the C-helix during the gating of cyclic nucleotide-gated channels.Effect of S6 tail mutations on charge movement in Shaker potassium channelsThe pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels.Concerted gating mechanism underlying KATP channel inhibition by ATP.In silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices.Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites.Ion permeation and selectivity in ClC-type chloride channels.The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers.Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+.Pore-opening mechanism in trimeric P2X receptor channelsIntracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor.KvAP-based model of the pore region of shaker potassium channel is consistent with cadmium- and ligand-binding experimentsPosition and motions of the S4 helix during opening of the Shaker potassium channel.Common mechanism of pore opening shared by five different potassium channelsVoltage regulation of connexin channel conductance.S6 peptide derived from KvAP channel shows cooperativity in gating on bilayer lipid membraneCharge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathyDisulfide trapping the mechanosensitive channel MscL into a gating-transition state.Status of the intracellular gate in the activated-not-open state of shaker K+ channelsThe emerging role of RNA editing in plasticity.Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel.
P2860
Q24644498-D18D75B5-90E5-44DA-9330-33795F37C345Q24657946-CEF89308-E17C-4702-973F-0697E1FB247AQ26829808-876234D8-2DF1-4C5F-8320-C2E24F32CAD1Q27021363-0AECA179-C356-43CB-9794-D08674248E4FQ28212998-5B58C8FD-68C6-4669-BF1A-C8114BCB861BQ28218385-6951DAC3-A9CC-45CB-A9F1-ADDFC9EC5A1BQ28359616-C18193D8-8855-45D7-BB03-C1AF8561249FQ30157611-DBFFC416-FF9A-450A-9508-F588709E4BFFQ30432912-846E2C54-BFE0-40D8-BC1F-B141CA64FF7CQ30476448-4610E969-5A87-4485-9A03-A7D18F39DC62Q33270767-D7E9DCBB-9E55-480D-BA78-4D6529E97E1FQ34141076-26D4E180-DCBE-4A32-B5FD-95D3A9EF3125Q34152898-1B25ACFE-D6B1-4981-95B1-F626578CB5AEQ34170649-72628EEE-074B-4DED-9679-9E816A7CBE83Q34170654-C6A5ADBD-15DD-4FB2-8B59-808A54FDEAFBQ34173224-F9968D24-9E45-4F17-9BF5-28E082BD8B28Q34173845-489EC287-2BFE-4FE0-A76A-170CB88D831DQ34179410-00B84269-3C32-48B0-AA28-1288F5673D4FQ34180133-6D7DD067-09AF-472E-BEB2-B1CB4037150AQ34181912-8E4F753C-4093-418C-8F13-28F94F9CCE42Q34185246-1C2B4E16-7C73-4C56-AFB0-61ED39FFFC0FQ34186991-BAE7D2A2-2025-425A-9613-1E9C9F636EEDQ34187668-A76C5F3E-D5BD-4FCA-84BF-71A462A7ADD6Q34211948-8650F787-8C4A-4B29-93B2-99C8E8E7D8C7Q34243021-ECD78EDE-214C-432B-A3DE-760F1FB7D0FDQ34309921-7BB7F00B-0F22-4654-9244-92596F6F0967Q34313783-4C880A67-A3A6-4767-B0C9-56E43042F7B5Q34315701-8796B350-B09A-416D-B847-5C7E7A730FE2Q34319244-7237B877-36C3-409A-B550-E053C2B3F11DQ34350671-3F937434-046C-43C5-9CDE-211156A1201DQ34368444-ED06346A-F77D-4613-8694-B37D26FDC141Q34600882-757F8468-4D59-47F7-A296-FD9C6109D3C0Q34774075-DA128464-8F9D-495F-800A-E8FD36563724Q35050366-33F64374-A684-4D1E-8D85-4B7BD149C24CQ35145307-F6776E3E-8071-4546-A64A-B4DA4D4555ECQ35235370-A1DCC3C8-BE05-4C5B-91B0-B6291EE62EC8Q35613680-71479F8C-1A1B-4633-80E3-FD13858B9C2EQ35629078-D3D909C4-1E3F-4D44-BC6C-C0D2FA09069FQ35803384-EAEAB62D-0686-40AD-932C-303DBF4DD614Q35808791-9EE3F957-807E-466A-8384-9E2EB00E0B3D
P2860
The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
The activation gate of a volta ...... an intersubunit metal bridge.
@en
type
label
The activation gate of a volta ...... an intersubunit metal bridge.
@en
prefLabel
The activation gate of a volta ...... an intersubunit metal bridge.
@en
P2093
P1433
P1476
The activation gate of a volta ...... an intersubunit metal bridge.
@en
P2093
P304
P356
10.1016/S0896-6273(00)80571-1
P407
P577
1998-09-01T00:00:00Z