Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling. - Wikidata - awgldk - TriplyDB

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.

http://www.wikidata.org/entity/Q42059392

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Mechanisms of granulin deficiency: lessons from cellular and animal models A shift to organismal stress resistance in programmed cell death mutants Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease.Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions.In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin.Lithospermic acid attenuates 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways.Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms.Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment.Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.Umbilical cord blood mesenchymal stem cells protect amyloid-β42 neurotoxicity via paracrine Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features Progranulin Reduced Neuronal Cell Death by Activation of Sortilin 1 Signaling Pathways After Subarachnoid Hemorrhage in Rats.Advances in understanding the molecular basis of frontotemporal dementia.Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells.Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B.Progranulin deficiency promotes post-ischemic blood-brain barrier disruption Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells.Progranulin axis and recent developments in frontotemporal lobar degeneration Progranulin protects lung epithelial cells from cigarette smoking-induced apoptosis.Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15.Progranulin Mutations Affects Brain Oscillatory Activity in Fronto-Temporal Dementia.Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.Progranulin Deficiency Reduces CDK4/6/pRb Activation and Survival of Human Neuroblastoma SH-SY5Y Cells.Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells.Circulating progranulin as a biomarker for neurodegenerative diseases Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors.The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.

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Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.

http://www.wikidata.org/entity/Q42059392

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Extracellular progranulin prot ...... activating survival signaling.

@en

Extracellular progranulin prot ...... activating survival signaling.

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type

label

Extracellular progranulin prot ...... activating survival signaling.

@en

Extracellular progranulin prot ...... activating survival signaling.

@nl

prefLabel

Extracellular progranulin prot ...... activating survival signaling.

@en

Extracellular progranulin prot ...... activating survival signaling.

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J.NEUROBIOLAGING.2011.06.017

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Neurobiology of Aging

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Extracellular progranulin prot ...... activating survival signaling.

@en

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Ioannis Papazoglou

http://www.w3.org/2001/XMLSchema#string

Jindong Xu

http://www.w3.org/2001/XMLSchema#string

Julien Bruban

http://www.w3.org/2001/XMLSchema#string

Junichi Shioi

http://www.w3.org/2001/XMLSchema#string

Kostas Vekrellis

http://www.w3.org/2001/XMLSchema#string

Maria Xilouri

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Nikolaos K Robakis

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Zhiping Shao

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P2860

The RSK family of kinases: emerging roles in cellular signalling

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth

Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.

Cellular localization of gene expression for progranulin.

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2326.e5-16

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scholarly article

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10.1016/J.NEUROBIOLAGING.2011.06.017

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12

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32

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2011-08-04T00:00:00Z

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233862554

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21820214

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3375317

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