DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
about
Ku binds telomeric DNA in vitroKu86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response elementShorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in ArtemisBeyond DNA repair: DNA-PK function in cancerRecruitment and activation of the ATM kinase in the absence of DNA-damage sensors.Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cellsDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsUtilization of oriented peptide libraries to identify substrate motifs selected by ATM.Computational analysis of retrovirus-induced scid cell death.Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma modelHomozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndromeDifferential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.Ku86 is essential in human somatic cells.The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinaseIrradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaserAAV-mediated tumorigenesis: still unresolved after an AAV assaultMutation of NIMA-related kinase 1 (NEK1) leads to chromosome instabilityPerturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapyRegulation of cell differentiation by the DNA damage response.Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.The life and death of DNA-PK.Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification.Cell Differentiation and Checkpoint.Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.Target cell frequency is a genetically determined risk factor in radiation leukaemogenesis.HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinaseImpaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.DNA repair: the link between primary immunodeficiency and cancer.DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues.DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.Roles of DNA Damage Response Proteins in Mitogen-Induced Thp-1 Differentiation into Macrophage.
P2860
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P2860
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
@en
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
@nl
type
label
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
@en
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
@nl
prefLabel
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
@en
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
@nl
P2093
P356
P1433
P1476
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
@en
P2093
Fleischmann RD
Gottesman MM
Morse HC 3rd
P2860
P2888
P304
P356
10.1038/NG1297-483
P407
P577
1997-12-01T00:00:00Z
P6179
1044509719