Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel.
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A cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gatingRobust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric ModulatorsRegulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain.ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.Phosphorylation of CFTR by PKA promotes binding of the regulatory domainAn electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening.A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle.Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation.Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating schemePreferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domainsDistinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel.The CFTR ion channel: gating, regulation, and anion permeationLong-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channelsConverting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsA functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solutionHow Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanismsRegulation of ABC transporter function via phosphorylation by protein kinases.A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporterRevertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR.NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR.The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics.Deletion of phenylalanine 508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels.Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains.Cysteine substitutions reveal dual functions of the amino-terminal tail in cystic fibrosis transmembrane conductance regulator channel gating.Apparent affinity of CFTR for ATP is increased by continuous kinase activity.Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation.Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain of CFTR.Regulation of murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in Chinese hamster ovary cells.Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.
P2860
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P2860
Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Dibasic protein kinase A sites ...... ce regulator chloride channel.
@en
Dibasic protein kinase A sites ...... ce regulator chloride channel.
@nl
type
label
Dibasic protein kinase A sites ...... ce regulator chloride channel.
@en
Dibasic protein kinase A sites ...... ce regulator chloride channel.
@nl
prefLabel
Dibasic protein kinase A sites ...... ce regulator chloride channel.
@en
Dibasic protein kinase A sites ...... ce regulator chloride channel.
@nl
P2093
P2860
P1476
Dibasic protein kinase A sites ...... ce regulator chloride channel.
@en
P2093
Hanrahan JW
Mathews CJ
Riordan JR
Tabcharani JA
P2860
P304
P356
10.1111/J.1469-7793.1998.365BQ.X
P407
P478
508 ( Pt 2)
P577
1998-04-01T00:00:00Z