Rapid activation of ATR by ionizing radiation requires ATM and Mre11 - Test2 - elhamkhani - TriplyDB

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

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The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks Human CtIP promotes DNA end resection Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1 ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor Targeting ATM-deficient CLL through interference with DNA repair pathways Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors.Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks.Roles of Chk1 in cell biology and cancer therapy The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent ATR: an essential regulator of genome integrity Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway DDB1 maintains genome integrity through regulation of Cdt1 Function of the ATR N-terminal domain revealed by an ATM/ATR chimera.ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.Effects of atmospheric pressure plasmas on isolated and cellular DNA-a review Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication.A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast And-1 is required for homologous recombination repair by regulating DNA end resection.MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.Ataxin-3 promotes genome integrity by stabilizing Chk1.Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival.Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel.The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.The DNA-damage response: new molecular insights and new approaches to cancer therapy

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

http://www.wikidata.org/entity/Q24680246

description

2006 nî lūn-bûn

@nan

2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

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2006年論文

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2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

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2006年论文

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name

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

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type

label

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

@ast

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

@en

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

@nl

prefLabel

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

@ast

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

@en

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

@nl

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Journal of Biological Chemistry

P1476

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

@en

P2093

David Cortez

http://www.w3.org/2001/XMLSchema#string

Jeremy S Myers

http://www.w3.org/2001/XMLSchema#string

P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

P304

9346-50

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scholarly article

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10.1074/JBC.M513265200

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P407

P433

14

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281

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2006-04-07T00:00:00Z

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16431910

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1821075

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