Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex - Test2 - elhamkhani - TriplyDB

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

http://www.wikidata.org/entity/Q24559347

about

Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways Overexpression of s6 kinase 1 in brain tumours is associated with induction of hypoxia-responsive genes and predicts patients' survival Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR Structural analysis and functional implications of the negative mTORC1 regulator REDD1 Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.Regulation of mTOR and cell growth in response to energy stress by REDD1.Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis The mTOR signalling pathway in human cancer The tuberous sclerosis complex Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy An emerging role for TOR signaling in mammalian tissue and stem cell physiology State of the science: an update on renal cell carcinoma mTOR: from growth signal integration to cancer, diabetes and ageing mTOR signaling in growth control and disease Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway The TSC1-TSC2 complex: a molecular switchboard controlling cell growth Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects Placental Responses to Changes in the Maternal Environment Determine Fetal Growth Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity The mTOR pathway and integrating immune regulation Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift Nuclear lamins and oxidative stress in cell proliferation and longevity Use of mTOR inhibitors in the treatment of breast cancer: an evaluation of factors that influence patient outcomes Amino acids and mTORC1: from lysosomes to disease Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Nutrient-sensing mechanisms across evolution Autophagy and cancer cell metabolism Nutrient sensing, metabolism, and cell growth control Regulation of mTORC1 by amino acids HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

http://www.wikidata.org/entity/Q24559347

description

2004 nî lūn-bûn

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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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Regulation of mTOR function in ...... /TSC2 tumor suppressor complex

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Brendan D Manning

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Ernst Hafen

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James Brugarolas

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Jan H Reiling

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Kui Lei

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Lee A Witters

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Leif W Ellisen

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Rebecca L Hurley

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

The phosphoinositide 3-kinase pathway

TSC2 mediates cellular energy response to control cell growth and survival

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2893-904

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scholarly article

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1632874

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10.1101/GAD.1256804

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23

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18

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William G. Kaelin

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2004-12-01T00:00:00Z

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8180701

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15545625

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534650

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