Loss of Geminin induces rereplication in the presence of functional p53
about
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinIdas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionTwo E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpointDisruption of mechanisms that prevent rereplication triggers a DNA damage responseGeminin regulates neuronal differentiation by antagonizing Brg1 activityThe chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Regulation of replication licensing by acetyltransferase Hbo1.Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damageHuman geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosisPrevention of DNA re-replication in eukaryotic cellsDifferentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activityReplication licensing and cancer--a fatal entanglement?Selective killing of cancer cells by suppression of geminin activityPreventing re-replication of chromosomal DNA.Functional domains of the Xenopus replication licensing factor Cdt1Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extractsThe Non-Canonical Role of Aurora-A in DNA ReplicationGenomic instability in cancer.Re-replication of a centromere induces chromosomal instability and aneuploidyThe Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication LicensingReverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenanceRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityReplication fork instability and the consequences of fork collisions from rereplicationCDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiationPCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitinationCellular checkpoint mechanisms monitoring proper initiation of DNA replicationOncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationAurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication.The APC/C inhibitor, Emi1, is essential for prevention of rereplicationAPC/C--the master controller of origin licensing?ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication.Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/CReplication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.DDB1 maintains genome integrity through regulation of Cdt1The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.Checkpoint effects and telomere amplification during DNA re-replication in fission yeast.Cdk2 is required for p53-independent G2/M checkpoint control.
P2860
Q24298173-ABEFF435-00A0-4C49-8A54-716D0023931FQ24301413-E82F022C-0D74-4772-82A0-B8F5E22E97A7Q24304921-96B426F4-24D1-45FC-AF6F-E00D8E894050Q24312094-3DA9376C-B562-44C9-93E6-68AA169BA59AQ24529993-C12804D7-1507-4E47-B821-660C6D96B28EQ24531381-97BB895D-914F-4126-8DBF-FC14B03A9084Q24537591-F579F6A7-29C4-4F38-8E3E-50A928CCAA4AQ24537658-30D2C08E-5D6D-4A47-A630-B67B022E645CQ24544016-8EAB6024-56CF-42D7-983B-D7338704ADE1Q24558657-04FF1430-182E-4AC5-8AB4-964ACFEF80A9Q24563189-DE675247-0F97-44B7-8455-445EB03B359FQ24632601-BEA088CA-C4B6-4CBB-85FC-DCB26159C59AQ24644745-E73C16E9-B55B-4423-B38F-3E2AFFCF6807Q24644766-0F66047C-5439-4D3B-BE62-8ED73407F947Q24648529-11F1875A-450F-4816-9AA7-0CEC2BD528D5Q24653685-C94981DE-937B-4519-BB84-133A206F77B5Q24794160-0D9B1364-75EE-4D59-B78D-7EBC70CBFE26Q24802342-E3399169-0972-44D2-9FE6-4A87DA34E0BEQ26784066-5FAFBEA7-BE75-46B1-8769-EF2EFF82E77AQ27013707-D6681376-1564-4078-95FC-3C8BFF50AB00Q27311421-6857E6B6-1037-4E59-A95A-BDFDC89F16DEQ27680038-7AD0CBCF-456D-4491-8A65-09D89DFCA1C7Q27935182-DFCC6574-8ACF-4129-A636-5B275A1029FCQ28068574-CFEE2FA2-97EC-4198-8F01-54251722D019Q28076969-37A88DD4-C51D-4FF7-BFC7-E00724B18912Q28290857-CB451511-A4B1-4846-BC53-64771CCA2C68Q28291192-8252B881-3528-465E-BFAB-92C797526CC4Q28297754-81FDC342-B8AE-47BE-ACFE-89563181EDD3Q29617915-8E4EC464-A12D-4A52-ACA3-2F93E7C3D38BQ30418865-C6F54085-C7B7-4A7C-8AC8-6BF3FF774C0CQ30440621-6053E43F-B1C6-49C0-B80D-D29246929466Q30442630-21288EBE-A0BA-4198-8994-0EF62DE892C2Q30443022-54C9700E-3EB8-4E42-8731-F0A40A4B55A7Q30444319-31331B96-9746-4067-BE3B-893AECEABE29Q30480589-599387C0-89DB-4F93-87B1-A8C682468CD5Q31136186-3C1E1541-4958-4BAA-B01E-946919AF5C12Q33255742-6C07210C-019E-4183-A60D-4B36BB03F1F7Q33294960-F735C0C2-79C2-40B3-9B27-840A6E23E7A2Q33312107-124246CA-9717-407C-B6EA-8BFF799B6B83Q33535880-27CDC9F1-CA43-4431-94D5-AC4C00145078
P2860
Loss of Geminin induces rereplication in the presence of functional p53
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Loss of Geminin induces rereplication in the presence of functional p53
@ast
Loss of Geminin induces rereplication in the presence of functional p53
@en
Loss of Geminin induces rereplication in the presence of functional p53
@nl
type
label
Loss of Geminin induces rereplication in the presence of functional p53
@ast
Loss of Geminin induces rereplication in the presence of functional p53
@en
Loss of Geminin induces rereplication in the presence of functional p53
@nl
prefLabel
Loss of Geminin induces rereplication in the presence of functional p53
@ast
Loss of Geminin induces rereplication in the presence of functional p53
@en
Loss of Geminin induces rereplication in the presence of functional p53
@nl
P2093
P2860
P50
P3181
P356
P1476
Loss of Geminin induces rereplication in the presence of functional p53
@en
P2093
Andrea Ballabeni
Laura Masiero
Marina Melixetian
Raffaella Zamponi
P2860
P304
P3181
P356
10.1083/JCB.200403106
P407
P577
2004-05-24T00:00:00Z