Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes - Test2 - elhamkhani - TriplyDB

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes

http://www.wikidata.org/entity/Q28236619

about

CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function Zinc finger proteins in cancer progression Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies Chromatin targeting drugs in cancer and immunity RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation Selective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage Progression The emerging role of GATA transcription factors in development and disease The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3 Targeting bromodomains: epigenetic readers of lysine acetylation The mechanisms behind the therapeutic activity of BET bromodomain inhibition Functions of BET proteins in erythroid gene expression Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery Targeting BET bromodomains for cancer treatment Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor BET domain co-regulators in obesity, inflammation and cancer The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development Drug Discovery Targeting Bromodomain-Containing Protein 4.Selective BET bromodomain inhibition as an antifungal therapeutic strategy Protein kinase D-HDAC5 signaling regulates erythropoiesis and contributes to erythropoietin cross-talk with GATA1 The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.Characterization of BRD4 during mammalian postmeiotic sperm development.The BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila.Writers and readers of histone acetylation: structure, mechanism, and inhibition Role of BRD4 in hematopoietic differentiation of embryonic stem cells.BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia Modification of enhancer chromatin: what, how, and why?BET bromodomain inhibitors: a patent review.Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.Bdf1 Bromodomains Are Essential for Meiosis and the Expression of Meiotic-Specific Genes.

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Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes

http://www.wikidata.org/entity/Q28236619

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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type

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Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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prefLabel

Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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PNAS.1102140108

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Proceedings of the National Academy of Sciences of the United States of America

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Bromodomain protein Brd3 assoc ...... ancy at erythroid target genes

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Gerd A Blobel

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Hongxin Wang

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Janine M Lamonica

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Stephan Kadauke

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Wulan Deng

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Yong Cheng

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P2860

Structure and ligand of a histone acetyltransferase bromodomain

Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1

Selective inhibition of BET bromodomains

Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation

The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription

Acetylation of histones and transcription-related factors

Combinatorial patterns of histone acetylations and methylations in the human genome

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99009

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10.1073/PNAS.1102140108

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22

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108

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Roland Gamsjaeger

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2011-05-31T00:00:00Z

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51092940

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21536911

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3107332

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