Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis
about
Centriole assembly and the role of Mps1: defensible or dispensable?Phosphorylation at serine 331 is required for Aurora B activation.Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpointKinetochore-microtubule interactions: steps towards bi-orientationThe final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinasesCell division: control of the chromosomal passenger complex in time and spaceLoss of the Greatwall Kinase Weakens the Spindle Assembly CheckpointA TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora BCentrosome - a promising anti-cancer targetQuantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpointSustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.Mps1 promotes rapid centromere accumulation of Aurora B.Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylationCharacterization of novel MPS1 inhibitors with preclinical anticancer activityThe MPS1 family of protein kinases.Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacyDissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversineConditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progressionSpindle checkpoint silencing: ensuring rapid and concerted anaphase onsetSensing centromere tension: Aurora B and the regulation of kinetochore function.TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast.A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint ArrestsDynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachmentSpindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.Selective killing of p53-deficient cancer cells by SP600125.Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.Mps1 kinase regulates tumor cell viability via its novel role in mitochondriaMonopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complexSpindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasisA chemical tool box defines mitotic and interphase roles for Mps1 kinase.Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle.Mps1 is SUMO-modified during the cell cycle.
P2860
Q21203546-E9C3E87C-8E0E-44EA-AD0A-CFAE6BCB9EEAQ24294588-4F40CB7B-612C-4C1F-8F3D-D1A1468C272FQ24315748-4CB8CBE9-A233-42FA-A770-E8B0DCBD233FQ24602097-6DFCE642-CE06-4AF5-87AE-626693E5BE16Q26823414-1921EF5A-BFC2-43BA-9CAF-60EE82426374Q26998631-448BEE33-602C-4B0E-B161-43579E0D6D63Q27307873-29BA1543-97EC-456A-86FB-9D8B3E057281Q27677259-3872E592-2E92-4677-B628-1D22312A95A2Q28077520-D9E0F26F-25C0-45FA-9653-445E0C130E1FQ28477755-AC7E3AA3-B2AC-430F-B71B-C422FCCDAE9AQ28603755-56D74822-24B2-4E52-B5CA-6C403AAA6D5BQ30477599-EAE93914-6CC7-4ACC-AD8B-E33DF2BC6773Q30524672-E445BC29-E543-4D1F-B366-1800805CB9B0Q30540597-15773207-153C-4ADA-A890-157E7801D43AQ30549643-088CF4C7-1796-42E1-805A-0ED85640C81FQ33632369-21B23207-685F-457A-A04A-7085BB70F87FQ33639719-96511D8A-0232-4C17-B2DA-A22E25D7BEB9Q34026669-FC393436-BC6D-48BA-B056-503FCC35D320Q34040427-20D78EDF-6C14-449D-BB67-25365C79FA85Q34263732-9BD44F04-4A07-4778-8106-0DD73E85D02CQ34343856-D937BE6B-35BA-4824-8A33-A7015E2A88C7Q34629172-1DB78017-D466-4C9D-9057-0BE6A094C404Q34735167-4078E943-E1CB-40CE-9180-1058253359C0Q34888095-7F8F845D-F6B8-4417-8C8A-57FB97888F2FQ35178292-B63386BA-BD48-49B1-B058-B8858F6C0CFFQ35241521-A98A197E-A6FF-4F1E-83FD-CD5E304F287EQ35632434-E74C106F-FD47-4285-9EB0-FBD9BDFC14A3Q35925170-48800439-E6F4-43AB-88BE-41E0E9439E90Q35989892-6A4D115A-CF47-411B-88F5-FCDAD75520E3Q36030477-C64C4685-CC6D-4241-B229-ABA3773A8A75Q36238666-8101F86A-44F6-49F2-BCBB-5BD8B65FFA61Q36336091-66393929-2D9E-489E-B7A1-8A0AC1E7F89EQ36879638-EB1218CB-BB26-41EF-BC02-57C37D646B91Q37151487-E4B7BE32-D1BC-40C6-8098-BA7B2CF94FA7Q37368640-1A298504-72F7-4823-BB90-71C478A01A6CQ37411011-8B30AAE4-D86F-45CC-98F9-3A9689071E86Q37772019-58629B00-A90E-4FBD-BB36-7525740A3724Q38025305-82D3CCBF-354A-4DDD-9FC2-B9EED4080021Q38743234-1373B8AD-79BF-4376-A6CB-FD5611022C60Q38811321-E08E816D-FAD1-4245-9A97-D52E1B47D887
P2860
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@ast
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@en
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@nl
type
label
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@ast
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@en
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@nl
prefLabel
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@ast
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@en
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@nl
P2093
P2860
P3181
P1433
P1476
Chemical genetic inhibition of ...... ts of Mps1 function in mitosis
@en
P2093
Chao Zhang
Geert J P L Kops
Kevan M Shokat
Tale Sliedrecht
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0010251
P407
P577
2010-04-22T00:00:00Z