The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
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Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cellsThe regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cellsA dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replicationChromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosisCell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1Mutations in the pre-replication complex cause Meier-Gorlin syndromeATP bound to the origin recognition complex is important for preRC formationLicensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extractsIn the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage fociThe human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cellsCDC6: from DNA replication to cell cycle checkpoints and oncogenesisDNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.Xenopus Cdc6 performs separate functions in initiating DNA replicationAnalysis of Cdc6 function in the assembly of mammalian prereplication complexesHda, a novel DnaA-related protein, regulates the replication cycle in Escherichia coliSynthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle.Mutation of cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cellsMicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway.Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro.Eukaryotic MCM proteins: beyond replication initiation.Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damageCleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis.ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6.Autophosphorylation of archaeal Cdc6 homologues is regulated by DNA.HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin.Modular organization of a Cdc6-like protein from the crenarchaeon Sulfolobus solfataricusCdc6 protein obstructs apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules.ATP-dependent pre-replicative complex assembly is facilitated by Adk1p in budding yeast.Mutations in the NB-ARC domain of I-2 that impair ATP hydrolysis cause autoactivation.Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro.Regulation of minichromosome maintenance helicase activity by Cdc6.Metazoan origin selection: origin recognition complex chromatin binding is regulated by CDC6 recruitment and ATP hydrolysis.Biochemical characterization of a CDC6-like protein from the crenarchaeon Sulfolobus solfataricus.The Replication Protein Cdc6 Suppresses Centrosome Over-Duplication in a Manner Independent of Its ATPase Activity.The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome.Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex; forming the pre-replicative complex (preRC)Study of DNA replication in Drosophila using cell free in vitro system.Different roles of the human Orc6 protein in the replication initiation process
P2860
Q24299362-7C369763-CDB1-4135-8020-96442424117DQ24301758-85C61B29-E5A6-4876-8DC2-1C11E37F2E38Q24304503-4F1C978E-B438-4E9A-9EE4-9A1D93414878Q24515107-64AA059F-3180-496B-94A3-E7871A5EC6E1Q24600785-5B3D7FAC-8AEA-456E-89EC-38751764BD22Q24629357-E6354F3F-1002-4393-BF53-70EDADFD7F18Q24630973-ABC4C3CA-67F4-47EB-80B5-6EF9BAC81F7CQ24802342-139F5141-5964-4631-945C-7AA1FE20B4D0Q27938355-C19F03DE-81B0-4852-AAA1-D3FB7E79B290Q28116217-020BFEF5-AF70-43FA-AAD3-C4A57AF3B1AFQ28139209-4D1BF8C9-6396-4DC7-AE1B-2DF64E5CD5A5Q28259261-6F69301D-AFE4-4BC8-B3C9-DEE8BA146863Q30847570-4013F50E-7F39-443F-94B6-63D398324D26Q33608362-0DB689EC-9CE8-4F07-8625-27D817247B3FQ34009304-FE599249-0913-4F1A-BF27-3B21CEDF0253Q34085669-22DD9AA6-105B-4F4F-93A5-23E231C13B43Q34114234-E8803EBD-DE0B-460A-8268-B12C859CF432Q34781402-111B98E7-21FC-4767-AF2E-6F80EA928423Q35093296-BA4ED195-CFE3-4251-A1DB-1ECD5044CBFCQ35197268-46DEE6FE-0D8C-4F03-A66D-7E1B0D7774DDQ35684975-9B166BBC-74C5-43E7-82D5-2361BC52BD0BQ35948990-CBF13E25-CFBE-4FA6-AC80-81ED9557C464Q36118202-4593B5A8-BDE1-41D5-8FF3-004F6D74EE06Q36125192-0AF1B127-1548-404F-A9D6-7ED89D411B30Q36534379-6BC689CC-6C95-493C-8916-C2736C90F19FQ39504873-5F1D4BC7-6F0E-43BF-BDDE-7D05C0E0C5E2Q39808778-338B2927-E6D1-4407-995F-2F5426A3EDFFQ41874528-C8128B05-B5A3-467C-8E93-C1708D6EA767Q42182866-3C623C9D-40B2-4E01-903A-EB686F16C5B4Q42423858-92D3B88E-A7CB-4E5B-AA5C-150A5E80B915Q42680832-75933C2C-3688-4292-B9A4-2D738323191BQ43876946-4D7492F0-D4A6-4121-9B48-80D85B67662EQ44499422-8814792C-1EA2-4BB9-8609-05780FA57914Q44594153-70220957-9CF1-4637-8A25-B9B59CEC34BDQ45935318-81873874-8EE1-49A5-BBA8-FA7923FA08D6Q47297306-F1E2FD05-7578-4D4F-AF80-6263C6AD235CQ47325448-0DBFAE06-DD48-43C1-9CF6-56EFD826DFE7Q50286268-E51FAA0A-F09B-4A1B-BAC2-2A0EE1FEA048Q52701321-43680C75-A7EE-4F1E-9948-BCDA3173F707Q58414588-4469D802-D738-4950-B276-218777845353
P2860
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
description
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im August 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/08/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/08/01)
@nl
наукова стаття, опублікована в серпні 1999
@uk
مقالة علمية (نشرت في أغسطس 1999)
@ar
name
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@ast
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@en
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@nl
type
label
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@ast
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@en
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@nl
prefLabel
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@ast
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@en
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@nl
P2093
P2860
P356
P1476
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells
@en
P2093
C. A. Marlar
E. Fanning
P2860
P304
P356
10.1091/MBC.10.8.2631
P577
1999-08-01T00:00:00Z