Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1 - Test2 - elhamkhani - TriplyDB

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

http://www.wikidata.org/entity/Q24600785

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The function of APC/CCdh1 in cell cycle and beyond Arsenite-induced Cdc25C Degradation is through the KEN-box and Ubiquitin-proteasome Pathway Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1 Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes.Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit Replication licensing and cancer--a fatal entanglement?Mechanisms to control rereplication and implications for cancer.Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts Insights into APC/C: from cellular function to diseases and therapeutics Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells.The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation Cell cycle-dependent proteolysis and phosphorylation of human Mcm10 Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms CDC6: from DNA replication to cell cycle checkpoints and oncogenesis Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box Dual mode of degradation of Cdc25 A phosphatase Cell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteins Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle.Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1 Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer.APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast.

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P2860

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

http://www.wikidata.org/entity/Q24600785

description

2000 nî lūn-bûn

@nan

2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

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2000年論文

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2000年論文

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2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

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2000年论文

@wuu

name

Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

@ast

Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

@en

Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

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type

label

Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

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Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

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Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

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prefLabel

Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

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Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

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Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

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Genes & Development

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Cell cycle- and cell growth-re ...... CDC6 is dependent on APC-CDH1

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B O Petersen

http://www.w3.org/2001/XMLSchema#string

C Gieffers

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C Matteucci

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C Wagener

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E Lazzerini Denchi

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F Marinoni

http://www.w3.org/2001/XMLSchema#string

J M Peters

http://www.w3.org/2001/XMLSchema#string

M Melixetian

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P2860

Geminin, an inhibitor of DNA replication, is degraded during mitosis

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

A human protein related to yeast Cdc6p

Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

Induction of S-phase entry by E2F transcription factors depends on their nuclear localization

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2330-2343

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scholarly article

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100876

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10.1101/GAD.832500

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18

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14

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2000-09-01T00:00:00Z

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277458495

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10995389

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316932

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