Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest
about
ATR suppresses endogenous DNA damage and allows completion of homologous recombination repairUnwinding and rewinding: double faces of helicase?Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombinationPRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryInteraction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndromeMPS1-dependent mitotic BLM phosphorylation is important for chromosome stabilityThe RecQ DNA helicases in DNA repairHuman RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biologyRoles of RECQ helicases in recombination based DNA repair, genomic stability and agingBLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasomeThe Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase deltaFunctional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestCrystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complexRecQ helicases in DNA double strand break repair and telomere maintenance.An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells.Preventing replication fork collapse to maintain genome integrityHpz1 modulates the G1-S transition in fission yeastMutation of the murine Bloom's syndrome gene produces global genome destabilizationATR: an essential regulator of genome integrityBLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.Unwinding protein complexes in ALTernative telomere maintenance.SUMO modification regulates BLM and RAD51 interaction at damaged replication forks.Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changesReplisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.RecQ helicases: guardian angels of the DNA replication fork.DNA replication arrest leads to enhanced homologous recombination and cell death in meristems of rice OsRecQl4 mutants.ATR contributes to telomere maintenance in human cellsThe HRDC domain of BLM is required for the dissolution of double Holliday junctionsDeficiency of Bloom syndrome helicase activity is radiomimeticRegulation of BLM Nucleolar LocalizationPhosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.The role of post-translational modifications in fine-tuning BLM helicase function during DNA repairTime to bloom.Genetic interactions between BLM and DNA ligase IV in human cells.Werner protein protects nonproliferating cells from oxidative DNA damageA small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
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P2860
Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Phosphorylation of the Bloom's ...... n recovery from S-phase arrest
@ast
Phosphorylation of the Bloom's ...... n recovery from S-phase arrest
@en
type
label
Phosphorylation of the Bloom's ...... n recovery from S-phase arrest
@ast
Phosphorylation of the Bloom's ...... n recovery from S-phase arrest
@en
prefLabel
Phosphorylation of the Bloom's ...... n recovery from S-phase arrest
@ast
Phosphorylation of the Bloom's ...... n recovery from S-phase arrest
@en
P2093
P2860
P1476
Phosphorylation of the Bloom's ...... n recovery from S-phase arrest
@en
P2093
Alwyn Dart
Ian D Hickson
Nicholas D Lakin
Phillip S North
Sally L Davies
P2860
P304
P356
10.1128/MCB.24.3.1279-1291.2004
P407
P577
2004-02-01T00:00:00Z