Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
about
Prevention of DNA re-replication in eukaryotic cellsThe Hect domain E3 ligase Tom1 and the F-box protein Dia2 control Cdc6 degradation in G1 phaseRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradationAurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factorPreferential re-replication of Drosophila heterochromatin in the absence of geminin.Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Replication licensing and the DNA damage checkpoint.CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.A high ratio of G1 to G0 phase cells and an accumulation of G1 phase cells before S phase progression after injurious stimuli in the proximal tubule.Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.Activation of a human chromosomal replication origin by protein tethering.Analysis of re-replication from deregulated origin licensing by DNA fiber spreadingGeminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.Flipping the switch from g1 to s phase with e3 ubiquitin ligasesFUCCI sensors: powerful new tools for analysis of cell proliferation.HUWE1 interacts with PCNA to alleviate replication stress.A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing.The spindle checkpoint, APC/C(Cdc20), and APC/C(Cdh1) play distinct roles in connecting mitosis to S phase.Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosisGeminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility.HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development
P2860
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P2860
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
@en
type
label
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
@en
prefLabel
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
@en
P2093
P2860
P356
P1476
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage
@en
P2093
Brandon D Bunker
Elizabeth S Dorn
Greg C Rogers
Hyun O Lee
Jonathan R Hall
P2860
P304
25356-25363
P356
10.1074/JBC.M802667200
P407
P577
2008-07-10T00:00:00Z