Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
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Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligasePriming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrateAutoregulation of Parkin activity through its ubiquitin-like domainThe F-box protein FBXO45 promotes the proteasome-dependent degradation of p73Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ERFBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51Dynamic regulation of the COP9 signalosome in response to DNA damageRapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substratesTRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesScaffold proteins: hubs for controlling the flow of cellular informationStructural basis for autoinhibition and phosphorylation-dependent activation of c-CblCysteine-based regulation of the CUL3 adaptor protein Keap1Control of cell growth by the SCF and APC/C ubiquitin ligasesUbiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathwaysThe structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functionsCullin-RING ligases in regulation of autophagyProtein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processesBuilding and remodelling Cullin-RING E3 ubiquitin ligasesAllosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp7860th residues of ubiquitin and Nedd8 are located out of E2-binding surfaces, but are important for K48 ubiquitin-linkageStructures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin LigasesStructure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding SurfaceA RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligasesBIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimerStructural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation EnzymesStructural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin LigasesSelective Recruitment of an E2 Ubiquitin Complex by an E3 Ubiquitin LigaseMolecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin LigasesCrystal structure and versatile functional roles of the COP9 signalosome subunit 1E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitinStructural and enzymatic characterization of a host-specificity determinant fromSalmonellaCycle inhibiting factors (cifs): cyclomodulins that usurp the ubiquitin-dependent degradation pathway of host cells.The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae.Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.A longevity protein, Lag2, interacts with SCF complex and regulates SCF functionDistinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BTwo Distinct Types of E3 Ligases Work in Unison to Regulate Substrate UbiquitylationPhosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localizationE2s: structurally economical and functionally replete
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Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
@en
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
@nl
type
label
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
@en
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
@nl
prefLabel
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
@en
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
@nl
P2860
P1433
P1476
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
@en
P2093
Anjanabha Saha
Raymond J Deshaies
P2860
P356
10.1016/J.MOLCEL.2008.08.021
P577
2008-10-01T00:00:00Z