Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
about
Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsGenes involved in pancreatic islet cell rejuvenationMapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and XaperonesTracking 20 years of compound-to-target output from literature and patentsA tale of two drug targets: the evolutionary history of BACE1 and BACE2Role of collectrin, an ACE2 homologue, in blood pressure homeostasis.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Automated assessment of β-cell area and density per islet and patient using TMEM27 and BACE2 immunofluorescence staining in human pancreatic β-cells.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.Targeting the β secretase BACE1 for Alzheimer's disease therapy.A general protocol for the generation of Nanobodies for structural biologyIdentification of Human Islet Amyloid Polypeptide as a BACE2 Substrate.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.The pancreatic beta cell surface proteome.Secretome protein enrichment identifies physiological BACE1 protease substrates in neuronsThe neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivoSystematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells.Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.New insights into gestational glucose metabolism: lessons learned from 21st century approachesBACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's diseaseA Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis.Genetics, genomics and metabolomics: new insights into maternal metabolism during pregnancy.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondBACE2 as a new diabetes target: a patent review (2010 - 2012).1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284).Proteomic identification of protease cleavage sites: cell-biological and biomedical applications.BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.New insights into the architecture of the islet of Langerhans: a focused cross-species assessment.Genetics of Gestational Diabetes Mellitus and Maternal Metabolism.Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.Emerging drugs to reduce abnormal β-amyloid protein in Alzheimer's disease patients.Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes.The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).β-cell preservation and regeneration for diabetes treatment: where are we now?Fishing for function--distinct roles of Bace1 and Bace2 in Zebrafish development.
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P2860
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
@en
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
@nl
type
label
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
@en
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
@nl
prefLabel
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
@en
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
@nl
P2093
P50
P921
P1433
P1476
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
@en
P2093
Alexander Schmidt
Bernhard Boehm
Cristiano Migliorini
Daria Esterházy
Domenico Bosco
Giatgen Andreia Spinas
Haiyan Wang
Hans Hilpert
Heinz Döbeli
Holger Moch
P304
P356
10.1016/J.CMET.2011.06.018
P577
2011-09-01T00:00:00Z