The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo - Test2 - elhamkhani - TriplyDB

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

http://www.wikidata.org/entity/Q36122127

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Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Synaptic Cell Adhesion Molecules in Alzheimer's Disease Interaction between therapeutic interventions for Alzheimer's disease and physiological Aβ clearance mechanisms Proteomic Substrate Identification for Membrane Proteases in the Brain β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortex Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease Targeting the β secretase BACE1 for Alzheimer's disease therapy.Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.Small Molecule Agonists of Cell Adhesion Molecule L1 Mimic L1 Functions In Vivo.η-Secretase processing of APP inhibits neuronal activity in the hippocampus.Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells.Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.β-Secretase: its biology as a therapeutic target in diseases Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.BACE1 activity regulates cell surface contactin-2 levels.A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production.Glia-based biomarkers and their functional role in the CNS.BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery.Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach.The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

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The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

http://www.wikidata.org/entity/Q36122127

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

@ast

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

@en

type

label

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

@ast

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

@en

prefLabel

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

@ast

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

@en

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JBC.M112.377465

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Journal of Biological Chemistry

P1476

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

@en

P2093

Diederik Moechars

http://www.w3.org/2001/XMLSchema#string

Harry Gijsen

http://www.w3.org/2001/XMLSchema#string

Katrijn Bockstael

http://www.w3.org/2001/XMLSchema#string

Lujia Zhou

http://www.w3.org/2001/XMLSchema#string

Marc Mercken

http://www.w3.org/2001/XMLSchema#string

Marianne Borgers

http://www.w3.org/2001/XMLSchema#string

Mathias Laga

http://www.w3.org/2001/XMLSchema#string

Soraia Barão

http://www.w3.org/2001/XMLSchema#string

Wim Annaert

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor

BACE (beta-secretase) modulates the processing of APLP2 in vivo

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation

Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration

An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

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25927-25940

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scholarly article

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10.1074/JBC.M112.377465

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P433

31

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P478

287

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Bart De Strooper

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2012-06-12T00:00:00Z

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22692213

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3406677

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