The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
about
Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfismMotif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulationThe spindle checkpoint and chromosome segregation in meiosisShort linear motifs - ex nihilo evolution of protein regulationApplication of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulansA TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora BTitin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-lineA Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding regionDrosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylationCenp-meta is required for sustained spindle checkpointConstruction of protein phosphorylation networks by data mining, text mining and ontology integration: analysis of the spindle checkpoint.Molecular basis of APC/C regulation by the spindle assembly checkpoint.A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signalingHow chromosome mis-segregation leads to cancer: lessons from BubR1 mouse modelsFunctional analysis of the Aspergillus nidulans kinome.Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancerSpatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulansMouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrestThe Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells.Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1.Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experimentsProbing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.Mammalian myosin-18A, a highly divergent myosin.Use of the protein ontology for multi-faceted analysis of biological processes: a case study of the spindle checkpointMaking an effective switch at the kinetochore by phosphorylation and dephosphorylation.BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancerArrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.Dawn of the dead: protein pseudokinases signal new adventures in cell biology.Techniques to examine nucleotide binding by pseudokinases.The molecular basis for kinesin functional specificity during mitosis.Centromeres and kinetochores of Brassicaceae.Signalling dynamics in the spindle checkpoint response.Going for broke: targeting the human cancer pseudokinome.Nucleotide-binding mechanisms in pseudokinases.Playing polo during mitosis: PLK1 takes the lead.The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.
P2860
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P2860
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
@en
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
@nl
type
label
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
@en
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
@nl
prefLabel
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
@en
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
@nl
P50
P1433
P1476
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase
@en
P2093
Mathijs Vleugel
Nina C Hubner
P304
P356
10.1016/J.DEVCEL.2012.03.009
P407
P50
P577
2012-06-01T00:00:00Z