Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature
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Targeting innate immunity for neurodegenerative disorders of the central nervous systemPim1 inhibition as a novel therapeutic strategy for Alzheimer's diseaseAlleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegenerationMaternal immune activation: Implications for neuropsychiatric disorders.mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease.p62 improves AD-like pathology by increasing autophagyThe mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.Insulin resistance in Alzheimer's disease.Fragile X mental retardation protein: from autism to neurodegenerative disease.Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathologyRapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy.Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.A Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer's Disease.The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease.The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy.Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic miceCollapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein TauIntraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.mTOR in Brain Physiology and Pathologies.Iron and Neurodegeneration: Is Ferritinophagy the Link?Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders.Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.Autophagy and Alzheimer's Disease.Nutritional strategies to optimise cognitive function in the aging brain.Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance.Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer's Disease?Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice.Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway.Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice.Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.Rapamycin Effectively Impedes Melamine-Induced Impairments of Cognition and Synaptic Plasticity in Wistar Rats.mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice.Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review.Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.
P2860
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P2860
Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Genetic reduction of mammalian ...... mpal gene expression signature
@ast
Genetic reduction of mammalian ...... mpal gene expression signature
@en
type
label
Genetic reduction of mammalian ...... mpal gene expression signature
@ast
Genetic reduction of mammalian ...... mpal gene expression signature
@en
prefLabel
Genetic reduction of mammalian ...... mpal gene expression signature
@ast
Genetic reduction of mammalian ...... mpal gene expression signature
@en
P2093
P2860
P1476
Genetic reduction of mammalian ...... mpal gene expression signature
@en
P2093
Angela Messina
Antonella Caccamo
Caterina Branca
Salvatore Oddo
P2860
P304
P356
10.1523/JNEUROSCI.0777-14.2014
P407
P577
2014-06-01T00:00:00Z