Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
about
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1Oncogenic Kras initiates leukemia in hematopoietic stem cellsNotch-1 regulates transcription of the epidermal growth factor receptor through p53.Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice.NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphomaModeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic miceNotch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Cyclin C is a haploinsufficient tumour suppressor.Human HMGA2 protein overexpressed in mice induces precursor T-cell lymphoblastic leukemiaDeletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma.c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-mycGenome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes.Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.Notch Signaling in T-Cell Development and T-ALLIllegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy.The double-edged sword of Notch signaling in cancer.p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasmsEnforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphomaFBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitorsThe SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemiaNotch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.Mechanisms of transcription factor deregulation in lymphoid cell transformation.The Notch signaling pathway as a mediator of tumor survivalNK/T-cell lymphomas in childrenNotch signaling in leukemia.Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia.Ikaros regulates Notch target gene expression in developing thymocytes.NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia.Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises.
P2860
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P2860
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@ast
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@en
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@nl
type
label
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@ast
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@en
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@nl
prefLabel
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@ast
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@en
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@nl
P2093
P2860
P1433
P1476
Notch1 mutations are important ...... precursor-T leukemia/lymphoma
@en
P2093
John J Letterio
Peter D Aplan
Rebecca A Nichols
Ying-Wei Lin
P2860
P304
P356
10.1182/BLOOD-2005-07-3013
P407
P577
2005-11-10T00:00:00Z