Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.
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Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsSrc homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migrationInterferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytesSalicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 MutationsMolecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 MutationsInhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphataseRole of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response.Discovery of phosphorylation motif mixtures in phosphoproteomics dataThe tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation.Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity.Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneityEyelid closure in embryogenesis is required for ocular adnexa developmentspe-29 encodes a small predicted membrane protein required for the initiation of sperm activation in Caenorhabditis elegans.Effects of HER2 overexpression on cell signaling networks governing proliferation and migration.Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.Ras-related signaling pathways in valve development: ebb and flow.Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation.Shp2 plays an important role in acute cigarette smoke-mediated lung inflammationShp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury.New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1.Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.SHP-2 expression negatively regulates NK cell function.Expression of signaling components in embryonic eyelid epithelium.Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestineSHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers.Src homology 2-containing protein tyrosine phosphatase-2 acts as a negative regulator for MUC5AC transcription via the inhibition of the ERK1/2 MAPK signalling pathway in the airway.Shp2 Deficiency Impairs the Inflammatory Response Against Haemophilus influenzae by Regulating Macrophage Polarization.Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice.E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells.EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors.ATL-1, an analogue of aspirin-triggered lipoxin A4, is a potent inhibitor of several steps in angiogenesis induced by vascular endothelial growth factor.Role of STAT3 in Transformation and Drug Resistance in CML
P2860
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P2860
Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Genetic evidence that Shp-2 ty ...... th factor receptor in mammals.
@ast
Genetic evidence that Shp-2 ty ...... th factor receptor in mammals.
@en
type
label
Genetic evidence that Shp-2 ty ...... th factor receptor in mammals.
@ast
Genetic evidence that Shp-2 ty ...... th factor receptor in mammals.
@en
prefLabel
Genetic evidence that Shp-2 ty ...... th factor receptor in mammals.
@ast
Genetic evidence that Shp-2 ty ...... th factor receptor in mammals.
@en
P2093
P2860
P356
P1476
Genetic evidence that Shp-2 ty ...... th factor receptor in mammals.
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.15.8528
P407
P577
1999-07-01T00:00:00Z